皮肤基底细胞癌发病机制及非手术治疗进展  

Advances in pathogenesis and non-surgical therapy of cutaneous basal cell carcinoma

作　　者：吴一晨 吴飞[1] 陈佳[1] Wu Yichen;Wu Fei;Chen Jia(Department of Pathology,Shanghai Skin Disease Hospital,School of Medicine,Tongji University,Shanghai 200443,China)

机构地区：[1]同济大学附属上海市皮肤病医院病理科,上海200443

出　　处：《肿瘤综合治疗电子杂志》2022年第4期15-20,共6页Journal of Multidisciplinary Cancer Management(Electronic Version)

基　　金：国家自然科学基金(81903215)。

摘　　要：皮肤基底细胞癌(basal cell carcinoma,BCC)是来自皮肤基底细胞的低度恶性肿瘤。Hedgehog信号通路异常激活、TP53等基因突变是其主要发病机制。特殊部位、皮损泛发及转移性BCC,需要非手术治疗作为重要补充甚至首选方案。非手术治疗包括以Hedgehog通路抑制剂为代表的药物治疗、光动力治疗、放疗、电化学治疗等。Basal cell carcinoma (BCC) is a low-grade malignant skin tumor originating from cutaneous basal cells.The abnormal activation of Hedgehog pathway and genetic mutations such as TP53 gene are the main pathogenesis of BCC.Non-surgical treatment is needed as an important supplement or even the preferred option for those whose lesions located in special sites,disseminated,or metastatic.Non-surgical treatment includes the medication represented by Hedgehog pathway inhibitors,photodynamic therapy,radiotherapy,electrochemical therapy and so on.

关 键 词：基底细胞癌 发病机制 治疗方式 

分 类 号：R739.5[医药卫生—肿瘤]