核转录因子TDP-43的病理作用及在疾病诊疗中的应用研究进展  

Research progress on the pathological effects of nuclear transcription factor TDP-43 and its application in disease diagnosis and treatment

作　　者：岳娇 李琴 杨兵 安豫 唐晓峰 陈颖梅 卢柯吉 王鹏 李公任 裴海峰 Yue Jiao;Li Qin;Yang Bing;An Yu;Tang Xiao-Feng;Chen Ying-Mei;Lu Ke-Ji;Wang Peng;Li Gong-Ren;Pei Hai-Feng(Department of Cardiology,General Hospital of Western Theater Command of Chinese PLA,Chengdu,Sichuan 610083,China;Clinical Medical College,Southwest Jiaotong University,Chengdu,Sichuan 610031,China;Cadre Ward,General Hospital of Western Theater Command of Chinese PLA,Chengdu,Sichuan 610083,China;Department of Cardiology and Nephrology,950th Hospital of Chinese PLA,Yecheng,Xinjiang 844900,China;College of Medicine and Life Sciences,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 611130,China)

机构地区：[1]解放军西部战区总医院心内科,四川成都610083 [2]西南交通大学医学院,四川成都610031 [3]解放军西部战区总医院干部病房,四川成都610083 [4]解放军第950医院心肾内科,新疆叶城844900 [5]成都中医药大学医学与生命科学学院,四川成都611130

出　　处：《解放军医学杂志》2022年第10期1026-1033,共8页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(81970241);西部战区总医院院管重点项目(2021-XZYG-A03)。

摘　　要：核转录因子TAR DNA结合蛋白43(TDP-43)是一种普遍表达且在进化上高度保守的DNA/RNA结合蛋白。在生理状态下,TDP-43主要定位于细胞核、细胞质(含量不超过30%)时可发挥生理学作用,如参与mRNA的转录、剪接、翻译、转运以及维持mRNA的稳定性等,若错误定位于线粒体则发挥相应的病理作用。近年来的研究发现,除了在神经退行性疾病中发挥作用外,TDP-43还在肿瘤、男性不育和骨性关节炎(OA)等其他疾病的病理进程中起重要作用。因此,TDP-43的基因表达、亚细胞器转位、功能以及与疾病的关系越来越受到关注。本文对TDP-43的病理作用及其在疾病诊疗中的应用研究进展进行综述,以期为相关疾病的诊断及治疗提供更多帮助。Nuclear transcription factor TAR DNA-binding protein 43 (TDP-43) is a DNA/RNA binding protein commonly expressed and highly conserved in evolution.In physiological state,TDP-43,when localized mainly in nucleus and cytoplasm (no more than 30%),may play a physiological role,such as participating in mRNA transcription,splicing,translation,transport and maintaining the stability of mRNA,while its mislocalization in mitochondria might play a corresponding pathological role.Recent researches found that,in addition to produce a marked effect in neurodegenerative diseases,TDP-43 also plays an important role in the pathological process of tumors,male infertility,osteoarthritis (OA) and other diseases.Therefore,the gene expression,subcellular organelle translocation,function and the relationship with diseases of TDP-43 have attracted more and more attention.The research progress of pathological effects of TDP-43 has been reviewed in present paper,so as to provide more help for diagnosis and treatment of related diseases.

关 键 词：TAR DNA结合蛋白43 亚细胞定位 神经退行性疾病 病理学 

分 类 号：R363[医药卫生—病理学]