低氧诱导因子调控肾透明细胞癌进程的分子机制研究进展  

Research advance in the molecular mechanisms of hypoxic-inducible factor regulating the progression of renal clear cell carcinoma

作　　者：陈延萍 吴果 马孟丹 杨育宾 陈巍[1] CHEN Yanping;WU Guo;MA Mengdan;YANG Yubin;CHEN Wei(Institute of Translational Medicine,the First Affiliated Hospital of Shenzhen University,Shenzhen Second People's Hospital,Shenzhen,Guangdong,China,518036;Department of Pharmacy,Shantou University School of Medicine,Shantou,Guangdong,China,515041)

机构地区：[1]深圳大学第一附属医院深圳市第二人民医院转化医学研究院,广东深圳518036 [2]汕头大学医学院药学系,广东汕头515041

出　　处：《分子诊断与治疗杂志》2022年第10期1641-1645,共5页Journal of Molecular Diagnostics and Therapy

基　　金：国家重点研发计划资助项目(2019YFA0906000);广东省自然科学基金项目(2020A1515010235)。

摘　　要：肾透明细胞癌(ccRCC)是泌尿系统最常见的肾恶性肿瘤之一,低氧诱导因子(HIF)在大多数肾透明细胞癌中高表达,是肿瘤生长过程中关键的调节因子。HIF通过与低氧反应元件(HER)结合介导其下游多个靶基因的转录,从而调控ccRCC发生、发展及多种生物学行为。本文主要围绕HIF基因对ccRCC的调控作用及机制进行综述,以期进一步明确其对基础医学的科学价值及对临床研究的指导作用。Clear cell renal cell carcinoma(ccRCC)is one of the most common malignant tumors in the urinary system. Hypoxia-inducible factor(HIF)is highly expressed in most renal clear cell carcinomas and is a key regulator of tumor growth. HIF mediates the transcription of multiple downstream target genes by binding to the hypoxia response element(HER),thereby regulating the occurrence,development,and various biological behaviors of ccRCC. This review focuses on the regulation and mechanism of HIF gene on ccRCC,to clarify its scientific value to basic medicine and its guiding role in clinical research.

关 键 词：肾透明细胞癌 低氧诱导因子 低氧反应元件 调控机制 

分 类 号：R737.11[医药卫生—肿瘤]