胶原蛋白肽改善皮肤的潜力及提升其生物利用度的对策  

Potential of collagen peptide to improve skin and the countermeasures to improve its bioavailability

作　　者：白磊 汪洋[1,2] 田晓静 王稳航 Bai Lei;Wang Yang;Tian Xiaojing;Wang Wenhang(College of Food Science and Technology,Tianjin University of Science and Technology,Tianjin 300457,China;Research&Development Center of Collagen Products,Xingjia Biotechnology Co.,Ltd.,Tianjin 300457,China)

机构地区：[1]天津科技大学食品科学与工程学院,天津市300457 [2]星甲(天津)生物技术有限公司卡勒贞产品开发中心,天津市300457

出　　处：《中国组织工程研究》2023年第21期3382-3390,共9页Chinese Journal of Tissue Engineering Research

基　　金：国家自然基金面上项目(32172249),项目负责人:王稳航;天津市合成生物技术创新能力提升行动专项(TSBICIP-KJGG-004),项目负责人:王稳航。

摘　　要：背景:胶原蛋白肽是由胶原蛋白水解而成的低分子质量活性肽,可经人体消化吸收,参与人体的蛋白质合成代谢,从而对皮肤健康产生积极作用,但目前胶原蛋白肽的吸收递送机制尚未完全明确,且存在着生物利用度低的问题。目的:文章探讨了提高胶原蛋白肽的生物利用度以促进皮肤改善的潜在措施。方法:用计算机检索ScienceDirect、PubMed、中国知网、Sci-Hub、百度学术数据库从2009年1月至2022年3月有关胶原蛋白肽制备、组成、消化及其生物利用度,皮肤构造、光老化及自然衰老,胶原蛋白肽口服体内运输机制、胶原蛋白肽透皮吸收机制及胶原蛋白肽与其他物质的协同吸收等相关文献,以“胶原蛋白、胶原蛋白肽、胶原蛋白肽制备、光老化、胶原蛋白肽经皮吸收”为中文检索词检索,以“collagen,collagen peptide,preparation of collagen peptide,photoaging,oral absorption”为英文检索词检索。最终纳入82篇文献进行综述分析。结果与结论:①光老化及自然衰老导致皮肤组织损伤,胶原蛋白肽可经口服胃肠消化后通过血液输送至皮肤,并通过内在分子机制构建皮肤组织,也可通过皮肤表层吸收对真皮层产生积极作用。②目前,口服胶原蛋白肽的生物利用度低且其递送机制主要集中在胃肠阶段,经皮吸收也存在表皮阻力过大的问题。③对于提高口服生物利用度应充分关注胶原蛋白肽的来源、氨基酸组成及肽序列,探究其分子质量、给药剂量及与不同物质或酶辅因子的协同吸收,寻找更多优质递送载体,以期提高胶原蛋白肽的生物利用度。④对于经皮吸收应充分利用先进技术、材料或改进后的物理化学方法降低皮肤物理阻力或提高分子渗透效率。⑤未来研究者们应考虑同时利用胶原蛋白肽口服与经皮吸收途径,以期实现更快、更有效地恢复光老化及自然衰老导致的皮肤组织问题。BACKGROUND:Collagen peptide is a low molecular active peptide obtained by hydrolysis of collagen.It can be digested and absorbed,and participate in protein synthesis and metabolism in the human body.It has a positive effect on skin health.However,the absorption and delivery mechanism of collagen peptides is not completely clear,and another problem is its low bioavailability.OBJECTIVE:To explore the potential measures to increase the bioavailability of collagen peptides for promoting skin health.METHODS:The articles related to the preparation,composition,digestion and bioavailability of collagen peptide,skin structure,photoaging and natural aging,transport mechanism of collagen peptide by oral in vivo,transdermal absorption mechanism of collagen peptide,and synergistic absorption of collagen peptide with other substances,were searched on ScienceDirect,PubMed,CNKI,Sci-Hub,and Baidu Academic Database from January 2009 to March 2022.The main keywords used were“collagen,collagen peptide,preparation of collagen peptide,photoaging,percutaneous absorption of collagen peptide”in Chinese and“collagen,collagen peptide,preparation of collagen peptide,photoaging,oral absorption”in English.Finally,82 articles were included for review.RESULTS AND CONCLUSION:(1)Photoaging and natural aging cause skin tissue damage.Collagen peptides can be transported to the skin through the blood after oral gastrointestinal digestion,and build skin tissue through internal molecular mechanisms,and can also be absorbed through the skin surface to have a positive effect on the dermis.(2)At present,the bioavailability of oral collagen peptide is low,and its delivery mechanism is mainly concentrated in the gastrointestinal stage,and there is also the problem of excessive epidermal resistance in percutaneous absorption.(3)The source,amino acid composition,peptide sequence,molecular weight and dosage of collagen peptide and synergistic absorption with different substances or enzyme cofactors should be paid more attention,looking for more high-q

关 键 词：胶原蛋白肽 皮肤结构 光老化 自然衰老 肠道吸收 经皮吸收 生物利用度 协同作用 分子渗透 

分 类 号：R459.9[医药卫生—治疗学] R363[医药卫生—临床医学] R751