清炎方治疗围绝经期复发性尿路感染  

Effect of Qingyan prescription in the treatment of perimenopausal patients with recurrent urinary tract infection

作　　者：汤璐敏[1] 车妙琳[2] 邹寒冰[3] 杨海芸[4] 邵兴华[2] 李鹤[1] 牟姗[2] TANG Lumin;CHE Miaolin;ZOU Hanbing;YANG Haiyun;SHAO Xinghua;LI He;MOU Shan(Department of Traditional Chinese Medicine,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Department of Nephrology,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Central Laboratory of Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Department of Geriatrics,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院中医科,上海200127 [2]上海交通大学医学院附属仁济医院肾内科,上海200127 [3]上海交通大学医学院附属仁济医院中心实验室,上海200127 [4]上海交通大学医学院附属仁济医院老年科,上海200127

出　　处：《长春中医药大学学报》2022年第11期1230-1233,共4页Journal of Changchun University of Chinese Medicine

基　　金：上海市科学技术委员会中医引导项目(13401905900);上海市卫生与健康委员会中医药项目(2018JP005)。

摘　　要：目的 探讨清炎方对围绝经期复发性尿路感染患者中医证候积分、外周血辅助性T细胞17(Th17)/调节性T细胞(Treg)细胞亚群及相关细胞因子的影响。方法 选择围绝经期复发性尿路感染患者68例,按随机数表法分为治疗组与对照组,各34例。治疗组予乳酸左氧氟沙星片治疗2周加清炎方治疗8周,对照组予乳酸左氧氟沙星片治疗2周。对比2组显效率、复发率以及中医证候积分。采用流式细胞仪技术检测患者外周血Th17/Treg细胞亚群,ELISA法检测血清细胞因子白介素-17(IL-17)和白介素-10(IL-10)水平。结果 治疗后,治疗组中医证候积分下降大于对照组(P<0.05)。治疗组有效率(97.1%,33/34)高于对照组(82.4%,28/34)(P<0.05),治疗组复发率(20.6%,7/34)低于对照组(50.0%,17/34)(P<0.05)。与治疗前比较,2组治疗后Th17细胞比例均下降(P<0.05),且治疗组低于对照组(P<0.05)。2组治疗后Treg细胞比例均上升,治疗组与治疗前差异明显(P<0.05)。治疗后,2组血清IL-17水平均下降(P<0.05),且治疗组低于对照组(P<0.05)。治疗后,治疗组血清IL-10水平高于治疗前(P<0.05),且高于对照组(P<0.05)。结论 清炎方可通过调节围绝经期复发性尿路感染患者Th17/Treg细胞亚群及其相关细胞因子表达,改善中医证候,防止复发。Objective To investigate the effects of the Qingyan prescription on the TCM syndrome scores,helper T cell 17 (Th17)/regulatory T cell (Treg) subsets in peripheral blood and related cytokines in perimenopausal patients with recurrent urinary tract infection.Methods Sixty-eight perimenopausal patients with recurrent urinary tract infection were randomly divided into a treatment group and a control group,with 34 cases in each group.The treatment group was treated with levofloxacin lactate tablets for 2 weeks as well as with the Qingyan prescription for 8 weeks,while the control group was only treated with levofloxacin lactate tablets for 2 weeks.The clinical effective rate,recurrence rate and TCM syndrome score were compared between the two groups.The Th17/Treg cell subsets in peripheral blood were detected by flow cytometry,and the levels of serum interleukin-17 (IL-17) and interleukin-10 (IL-10) were detected by ELISA.Results After treatment,the scores of TCM syndrome in the treatment group were decreased more than those in the control group (P<0.05).The effective rate in the treatment group (97.1%,33/34) was higher than that in the control group (82.4%,28/34) (P<0.05),while the recurrence rate in the treatment group (20.6%,7/34) was lower than that in the control group (50.0%,17/34) (P<0.05).Compared with before treatment,the proportions of Th17 cells in both groups were decreased after treatment (P<0.05),and the treatment group was lower than the control group (P<0.05).The proportions of Treg cells in both groups were increased after treatment,and the difference in the treatment group was significant (P<0.05).After treatment,the levels of serum IL-17 in both groups were decreased (P<0.05),and the treatment group was lower than the control group (P<0.05).After treatment,the level of serum IL-10 in the treatment group was higher than that before treatment (P<0.05),and higher than that in the control group (P<0.05).Conclusion In the treatment of perimenopausal patients with recurrent urinary tract infection,the Qin

关 键 词：复发性尿路感染 辅助性T细胞17 调节性T细胞 白介素-17 白介素-10 清炎方 

分 类 号：R743.3[医药卫生—神经病学与精神病学]