Hedgehog及WNT信号通路在眼睑基底细胞癌中的研究进展  

Research progress on Hedgehog and WNT signaling pathways in eyelid basal cell carcinoma

作　　者：陈佳静 李超鹏 王其龙[2] 王飞 Jia-Jing Chen;Chao-Peng Li;Qi-Long Wang;Fei Wang(Department of Ophthalmology,the Affliated Huai'an No.1 People's Hospital of Nanjing Medical University,Huai'an 223300,Jiangsu Province,China;Department of Key Laboratory,the Affliated Huai'an No.1 People's Hospital of Nanjing Medical University,Huai'an 223300,Jiangsu Province,China)

机构地区：[1]南京医科大学附属淮安第一医院眼科,中国江苏省淮安市223300 [2]南京医科大学附属淮安第一医院中心实验室,中国江苏省淮安市223300

出　　处：《国际眼科杂志》2022年第11期1822-1826,共5页International Eye Science

基　　金：淮安市科技项目(No.HAB202102)。

摘　　要：眼睑基底细胞癌(basal cell carcinoma,BCC)是最常见的眼睑恶性肿瘤。虽然眼睑BCC恶性程度及转移能力较低,但其发病率逐年上升,已受到临床医师的广泛重视。目前手术仍为一线治疗,但局部晚期眼睑BCC进行手术有导致毁容及眼部功能丧失的风险,因此仍然需要寻找新的治疗方案。研究显示多种信号通路的异常表达与其相关,尤其是Hedgehog信号通路及WNT信号通路,它们的激活在眼睑BCC中具有十分重要的意义,同时这两条通路也能够相互作用,共同介导眼睑BCC的发生发展。尽管近年来针对相关信号通路的靶向抑制剂开始应用于BCC的临床治疗,但用药后疾病复发、耐药及不良反应常见,因此迫切需要针对不同信号通路开发新的抑制剂。所以,本文综述了眼睑BCC中Hedgehog及WNT信号通路的最新研究进展,旨在为寻找BCC治疗的关键靶点提供重要的科学依据。Eyelid basal cell carcinoma(BCC)is the most common eyelid malignant tumor.Although eyelid BCC exhibits a relatively low malignancy and metastatic ability,its incidence is rising annually,and extensive attention has been received from clinicians.Currently,surgery is still the first-line treatment,but surgery for locally advanced eyelid BCC may lead to disfigurement and loss of eye function,so new treatment options are still needed.Studies have shown that the pathogenesis of eyelid BCC is associated with the abnormal expression of multiple signaling pathways,especially the Hedgehog and WNT signaling pathways.Their activation plays an important role in eyelid BCC,and these two pathways can also interact with each other to jointly mediate the development of eyelid BCC.Although targeted inhibitors targeting related signaling pathways have begun to be applied in the clinical treatment of eyelid BCC in recent years,disease recurrence,drug resistance and adverse reactions are still common after medication.Therefore,it is urgent to develop new inhibitors targeting different signaling pathways.Therefore,this paper reviews the recent progress on Hedgehog and WNT signaling pathways in eyelid BCC,aiming to provide important scientific basis for finding key targets for eyelid BCC therapy.

关 键 词：眼睑 基底细胞癌 HEDGEHOG信号通路 WNT信号通路 

分 类 号：R739.7[医药卫生—肿瘤]