ROR1在肺腺癌组织中的表达与气腔播散相关性  

Expressions of ROR1 in Lung Adenocarcinoma and Its Relationship with Spread Through Air Apace

作　　者：赵华君 潘国庆[2] 唐莹[3] 王智园 赵晓玮 陀晓宇 Huajun ZHAO;Guoqing PAN;Ying TANG;Zhiyuan WANG;Xiaowei ZHAO;Xiaoyu TUO(Mental Health Center Affiliated to Kunming Medical University,Kunming Yunnan 650224;Dept.of Pathology,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032;Electron Microscopy Lab,School of Basic Medicine,Kunming Medical University,Kunming Yunnan 650500,China)

机构地区：[1]昆明医科大学附属精神卫生中心,云南昆明650224 [2]昆明医科大学第一附属医院病理科,云南昆明650032 [3]昆明医科大学电镜室,云南昆明650500

出　　处：《昆明医科大学学报》2022年第11期22-29,共8页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202001AY070001-026;2018FE001-012);云南省教育厅科学研究基金资助项目(2019J1235)。

摘　　要：目的研究受体酪氨酸激酶样孤儿受体1(receptor tyrosine kinase-like orphan rectetpor 1,ROR1)在不同病理亚型肺腺癌组织中的表达与气腔播散(spread through air space,STAS)发生的关系。方法收集昆明医科大学第一附属医院病理科2017年6月至2022年1月,肺腺癌组织蜡块标本618例,采用HE染色切片判断病理亚型与病理特征,记数STAS数量并分级,免疫组化染色,半定量判读ROR1表达水平,统计分析ROR1表达与STAS数量及与病理亚型的关系。结果ROR1在微乳头型与实体型肺腺癌(低分化)中的表达高于其它亚型肺腺癌,差异有统计学意义(P<0.001);ROR1在低STAS、高STAS组中表达率分别为88.0%、94.1%,高于无STAS组且差异有统计学意义(P<0.001)。结论ROR1高表达于低分化肺腺癌并提示更高的STAS发生率。ROR1有望成为新的肺腺癌诊断生物标志物用于指导临床治疗及辅助预后判断,并可能成为STAS阳性肺腺癌的潜在治疗靶点。Objective To study the relationship between the expression of receptor tyrosine kinase-like orphan receptor 1(ROR1) and spread through air space(STAS) in lung adenocarcinoma tissues. Methods We collected 618 cases of lung adenocarcinoma from June 2017 to January 2,2022,HE staining section was used to determine pathological subtypes and pathological characteristics,count STAS number and grade. The expression of ROR1 was detected by immunohistochemistry staining in different pathological subtypes of lung adenocarcinoma and the relationship with STAS quantity was analyzed. Results ROR1 expressions were higher in micropapillary and solid lung adenocarcinoma(poorly differentiated)(P < 0.001);ROR1 expression rates were 88.0%,94.1% in low STAS and high STAS groups,significantly higher than no STAS group(P < 0.001). Conclusions ROR1 is highly expressed in poorly differentiated lung adenocarcinoma and suggests a higher incidence of STAS. ROR1 is expected to be a new diagnostic biomarker of lung adenocarcinoma for guiding clinical treatment and assisting prognostic judgment,and may be a potential therapeutic target for STAS-positive lung adenocarcinoma.

关 键 词：肺腺癌 ROR1 气腔播散 病理学亚型 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤] R366[医药卫生—临床医学] R36