加巴喷丁添加治疗难治性部分性癫痫患者的临床效果  

Clinical effect of gabapentin addition in the treatment of patients with refractory partial epilepsy

作　　者：李传斌[1] LI Chuanbin(Neurology Department,Zhoukou Central Hospital,Zhoukou 466000,China)

机构地区：[1]周口市中心医院神经内科,河南周口466000

出　　处：《临床医学研究与实践》2022年第31期59-61,共3页Clinical Research and Practice

摘　　要：目的探讨加巴喷丁添加治疗难治性部分性癫痫患者的临床效果。方法选取90例难治性部分性癫痫患者作为研究对象,以临床用药方案差异将其分为常规组(常规治疗)和观察组(加巴喷丁添加治疗),各45例。比较两组的临床效果。结果常规组的治疗总有效率低于观察组(P<0.05)。治疗后,两组的白细胞分化抗原3阳性(CD3^(+))、白细胞分化抗原4阳性(CD4^(+))均高于治疗前,白细胞分化抗原8阳性(CD8^(+))、血清免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平均低于治疗前,且观察组优于常规组(P<0.05)。观察组的恶心、嗜睡、纳差、共济失调发生率均低于常规组(P<0.05)。结论加巴喷丁添加治疗难治性部分性癫痫患者可取得理想的治疗效果,能有效稳定生化指标水平,降低不良反应发生率,且安全性较高,值得临床推广与应用。Objective To explore the clinical effect of gabapentin addition in the treatment of patients with refractory partial epilepsy.Methods A total of 90 patients with refractory partial epilepsy were selected as the research objects.According to the differences in clinical medication reqimen,the patients were divided into conventional group(conventional treatment)and observation group(gabapentin addition treatment),with 45 cases in each group.The clinical effects of the two groups were compared.Results The total effective rate of treatment of the conventional group was lower than that of the observation group(P<0.05).After treatment,the levels of cluster of differentiation 3 positive(CD3^(+))and cluster of differentiation 4 positive(CD4^(+))in the two groups were higher than those before treatment,the cluster of differentiation 8positive(CD8^(+)),serum immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)levels were lower than those before treatment,and those in the observation group were better than the conventional group(P<0.05).The incidences of nausea,drowsiness,anorexia and ataxia in the observation group were lower than those in the conventional group(P<0.05).Conclusion Gabapentin addition in the treatment of patients with refractory partial epilepsy can achieve ideal therapeutic effect,effectively stabilize the levels of biochemical indexes,reduce the incidence of adverse reactions,and has high safety,which is worthy of clinical promotion and application.

关 键 词：加巴喷丁 难治性部分性癫痫 免疫功能 

分 类 号：R742.1[医药卫生—神经病学与精神病学]