中性粒细胞/淋巴细胞比值对心源性脑栓塞患者90d死亡风险的预测价值  

Predictive value of neutrophil/lymphocyte ratio in 90-day risk of death in patients with cardioembolic stroke

作　　者：贾培飞 孙量[1] 乌兰[1] 李清华 吴丽娥[2] JIA Peifei;SUN Liang;WU Lan(Department of Neurology,The Second Affiliated Hospital of Baotou Medical College,Baotou 014030,China)

机构地区：[1]内蒙古科技大学包头医学院第二附属医院神经内科,内蒙古包头014030 [2]内蒙古科技大学包头医学院第一附属医院,内蒙古包头014000

出　　处：《中风与神经疾病杂志》2022年第10期913-915,共3页Journal of Apoplexy and Nervous Diseases

基　　金：包头医学院科学研究基金(BYJJ-YF-2018014)。

摘　　要：目的探讨中性粒细胞/淋巴细胞比值(NLR)对心源性脑栓塞(CE)患者90 d死亡风险的预测价值。方法对245例心源性脑栓塞患者进行回顾性分析。收集患者人口学资料、血管危险因素、实验室检查及终点事件发生情况。根据有无终点事件发生分为存活组和死亡组。采用多因素Logistic回归分析终点事件的影响因子,绘制ROC曲线,评价NLR对终点事件的预测价值。结果纳入分析245例,145例存活,100例患者死亡。与存活者比较,死亡组在年龄、高脂血症、房颤、mRS评分、白细胞计数、谷草转氨酶、中性粒细胞评分显著升高(P<0.01),两组在性别、高血压、糖尿病、家族史、吸烟、饮酒、红细胞计数、血红蛋白等血液指标方面差异无统计学意义(P>0.05)。多因素Logistic回归分析显示,年龄、房颤、高脂血症、NLR是90 d死亡的独立危险因素。ROC显示AUC=0.7558。当NLR的最佳截断值为5.65时,灵敏度为68.0%,特异度为76.6%。结论入院时NLR升高是心源性脑梗死患者90 d死亡的高危因素,对90 d死亡有较好的预测价值。Objective To explore the predictive value of neutrophil/lymphocyte ratio(NLR)on the 90 day mortality risk of patients with cardiogenic cerebral embolism(CE).Methods 245 patients with cardiogenic cerebral embolism were analyzed retrospectively.Demographic data,vascular risk factors,laboratory tests and end point events were collected.The patients were divided into survival group and death group according to whether or not there were end-point events.Multifactor logistic regression was used to analyze the influencing factors of endpoint events,to draw ROC curve,and to evaluate the predictive value of NLR on endpoint events.Results Of the 245 cases included in the analysis,145 survived and 100 died.Compared with the survivors,the age,hyperlipidemia,atrial fibrillation,mRS score,white blood cell count,glutathione aminotransferase and neutrophil score in the death group were significantly higher(P<0.01),and there was no significant difference in gender,hypertension,diabetes,family history,smoking,alcohol consumption,red blood cell count,hemoglobin and other blood indicators between the two groups(P>0.05).Multivariate logistic regression analysis showed that age,atrial fibrillation,hyperlipidemia and NLR were independent risk factors for 90-day death.ROC shows AUC=0.7558.When the optimal cutoff value of NLR was 5.65,the sensitivity was 68.0%,and the specificity was 76.6%.Conclusion The increase of NLR at admission is a high risk factor for 90 day death in patients with cardiogenic cerebral infarction,and it has a good predictive value for 90 day death.

关 键 词：中性粒细胞/淋巴细胞比值 心源性脑栓塞 死亡 预测价值 

分 类 号：R743.3[医药卫生—神经病学与精神病学]