胰腺癌小鼠模型研究进展  

Advances in mouse models of pancreatic cancer

作　　者：苗晋鑫[1] 张钟允[1] 王峥[1] 宋韶鹤 MIAO Jinxin;ZHANG Zhongyun;WANG Zheng;SONG Shaohe(Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450000,China;Department of Pharmacy,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000)

机构地区：[1]河南中医药大学中医药科学院,郑州450000 [2]河南中医药大学第一附属医院药学部,郑州450000

出　　处：《中国实验动物学报》2022年第5期713-719,共7页Acta Laboratorium Animalis Scientia Sinica

基　　金：中国博士后科学基金特别资助(2021T140184);河南省博士后科研项目(202001043);河南省自然科学基金青年项目(202300410259)。

摘　　要：胰腺癌是一种恶性程度高、预后极差的恶性癌症之一,发病率和死亡率不断上升。胰腺癌小鼠模型可以表征胰腺肿瘤特征,是研究癌症预防和治疗的最佳工具。胰腺癌小鼠模型分为诱导性模型、移植性模型和基因工程模型。然而,与人类胰腺癌相比,没有简单动物模型可以模拟人类胰腺癌的所有特征。已有胰腺癌小鼠模型各自用途不一,本文对不同胰腺癌小鼠模型的造模方法、特征及优缺点的研究进展做一综述,为胰腺癌疾病的研究提供理论依据。Malignant pancreatic cancers show a high degree of malignancy,a poor prognosis,and high rates of morbidity and mortality.Mouse models of pancreatic cancer demonstrate certain characteristics of human pancreatic tumors and are useful for studying cancer prevention and treatment.Mouse models are divided into induced,transplanted,and genetically engineered models,each of which shows specific characteristics of human pancreatic cancer.Various mouse models are reviewed in the present report.

关 键 词：胰腺癌 小鼠模型 移植性模型 基因工程 

分 类 号：Q95-33[生物学—动物学]