RhoA/ROCK通路调控小胶质细胞极化的研究进展  

Research progress in regulation of microglial polarization by RhoA/ROCK signaling pathway

作　　者：肖迎港 高巨 XIAO Yinggang;GAO Ju(Medical College of Yangzhou University,Yangzhou,Jiangsu,225009;Department of Anesthesiology,Northern Jiangsu People′s Hospital Affiliated to Yangzhou University,Yangzhou,Jiangsu,225001)

机构地区：[1]扬州大学医学院,江苏扬州225009 [2]扬州大学附属苏北人民医院麻醉科,江苏扬州225001

出　　处：《实用临床医药杂志》2022年第20期136-141,148,共7页Journal of Clinical Medicine in Practice

基　　金：国家自然科学基金资助项目(No.82172190)。

摘　　要：小胶质细胞广泛参与中枢神经系统的多种病理生理过程,其极化特性则与神经元的炎症反应和损伤修复密切相关。Ras同源基因家族蛋白A(RhoA)/Rho相关卷曲螺旋蛋白激酶(ROCK)信号通路对小胶质细胞极化具有重要的调控功能。目前,通过促进小胶质细胞M2型极化治疗神经元受损的相关研究已成为神经科学领域的热点之一,但RhoA/ROCK通路对极化的调控作用仍未明确。本文综述RhoA/ROCK信号通路对小胶质细胞极化的影响,以期为脑保护分子机制研究及临床治疗提供新思路。Microglia are widely involved in various pathophysiological processes of the central nervous system,and theiRpolarization characteristics are closely related to the inflammatory response and injury repaiRof neurons.Ras homologous gene family protein A(RhoA)/Rho-associated coiled-coil protein kinase(ROCK)signaling pathway plays an important role in regulating microglia polarization.At present,the related research on the treatment of neuronal damage by promoting microglial M2-type polarization has become one of the hot spots in the field of neuroscience,but the effect of RhoA/ROCK pathway on polarization is still unclear.This article reviewed the effect of RhoA/ROCK signaling pathway on microglial polarization in ordeRto provide new ideas foRthe study of moleculaRmechanism of brain protection and clinical treatment.

关 键 词：RHO因子 RHO相关激酶类 小胶质细胞 极化 炎症 脑损伤 

分 类 号：R741.02[医药卫生—神经病学与精神病学] R363.2[医药卫生—临床医学]