A Review of Nano/Micro/Milli Needles Fabrications for Biomedical Engineering  

作　　者：Bin Liu Xin Yi Ying Zheng Zhishan Yuan Jingbo Yang Jian Yang Xiao Yu Lelun Jiang Chengyong Wang 

机构地区：[1]Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments,School of Biomedical Engineering,Shenzhen Campus of Sun Yatsen University,Shenzhen 518107,China [2]Guangdong Provincial Key Laboratory of Minimally Invasive Surgical Instruments and Manufacturing Technology,School of Electromechanical Engineering,Guangdong University of Technology,Guangzhou 510006,China

出　　处：《Chinese Journal of Mechanical Engineering》2022年第3期51-79,共29页中国机械工程学报（英文版）

基　　金：National Natural Science Foundation of China(Grant Nos.52175446,51975133,51975597);Guangdong Basic and Applied Basic Research Foundation(Grant Nos.2021A1515011740,2019A1515011011);Shenzhen Fundamental Research Program(Grant No.JCYJ20170818163426597).

摘　　要：Needles,as some of the most widely used medical devices,have been effectively applied in human disease prevention,diagnosis,treatment,and rehabilitation.Thin 1D needle can easily penetrate cells/organs by generating highly localized stress with their sharp tips to achieve bioliquid sampling,biosensing,drug delivery,surgery,and other such applications.In this review,we provide an overview of multiscale needle fabrication techniques and their biomedical applications.Needles are classified as nanoneedles,microneedles and millineedles based on the needle diameter,and their fabrication techniques are highlighted.Nanoneedles bridge the inside and outside of cells,achieving intracellular electrical recording,biochemical sensing,and drug delivery.Microneedles penetrate the stratum corneum layer to detect biomarkers/bioelectricity in interstitial fluid and deliver drugs through the skin into the human circulatory system.Millineedles,including puncture,syringe,acupuncture and suture needles,are presented.Finally,conclusions and future perspectives for next-generation nano/micro/milli needles are discussed.

关 键 词：NANONEEDLES MICRONEEDLES Millineedles Fabrication methods Biomedical Engineering 

分 类 号：TH77[机械工程—仪器科学与技术]