益生菌对轻微型肝性脑病患者显性肝性脑病发生率影响的Meta分析  

Effect of probiotics in preventing overt hepatic encephalopathy in patients with minimal hepatic encephalopathy:A Meta-analysis

作　　者：姚俞昊 张嘉鑫[2,3] 夏潇 朱顺 李小科 叶永安[2,3] YAO Yuhao;ZHANG Jiaxin;XIA Xiao;ZHU Shun;LI Xiaoke;YE Yong’an(First School of Clinical Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Liver Diseases Academy of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100700,China;Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]北京中医药大学第一临床医学院,北京100029 [2]北京中医药大学东直门医院,北京100700 [3]北京中医药大学中医肝病研究院,北京100700 [4]中国中医科学院广安门医院,北京100053

出　　处：《临床肝胆病杂志》2022年第11期2505-2509,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金项目(82174341);国家中医药管理局科研基金项目(JDZX2015300);北京中医药大学新教师启动基金项目(2022-JYB-XJSJJ-050)。

摘　　要：目的评价使用益生菌干预对轻微型肝性脑病患者显性肝性脑病发生率的影响。方法本研究根据PRISMA指南完成,PROSPERO注册号为CRD42022303995。检索PubMed、Web of Science、Cochrane Library、知网、万方数据库,收集建库至2021年11月有关益生菌干预治疗轻微型肝性脑病的研究。用RevMan 5.4进行Meta分析,不能合并的数据采用描述性分析。选择危险比(RR)和95%CI作为汇总指标。结果共纳入6篇文献,均为随机对照研究,共404例轻微型肝性脑病患者。结果表明益生菌干预可使轻微型肝性脑病患者显性肝性脑病的发生率降低54%(RR=0.46,95%CI:0.26~0.81,P=0.007),并且能增加轻微型肝性脑病患者疾病的逆转率(RR=4.94,95%CI:2.82~8.66,P<0.00001)。结论益生菌能够降低轻微型肝性脑病患者显性肝性脑病的发生率,增加轻微型肝性脑病的逆转率,对轻微型肝性脑病患者预防显性肝性脑病的发生具有积极意义,为益生菌治疗轻微型肝性脑病提供了新的证据。Objective To review and analyze the effect of probiotics in preventing the overt hepatic encephalopathy(OHE)in patients with minimal hepatic encephalopathy(MHE).Methods Studies about this subject were searched in PubMed,Web of Science,Cochrane Library,Chinese journal full-text database(CNKI),WanFang data knowledge service platform(WanFang Data)from their establishment to November 2021.Meta-analysis was performed using RevMan 5.4.Description analysis was used for data that could not be pooled.The relative risk(RR)and 95%confidence interval(CI)were used to present pooled data.Results Six RCT studies with a total of 404 patients were included in this meta-analysis.The results showed probiotics users had a significant reduction of the OHE incidence,as compared with the controls(RR=0.46,95%CI:0.26-0.81;P=0.007),but an increase in the reversal MHE rate(RR=4.94,95%CI:2.82-8.66;P<0.00001).Conclusion This finding demonstrated that probiotics were able to effectively reduce the OHE incidence and improve the reversal MHE rate in the patients with MHE.This study could provide novel evidence for probiotics treatment of MHE.

关 键 词：肝性脑病 益生菌 META分析 

分 类 号：R575.3[医药卫生—消化系统]