肝细胞癌中细胞因子信号传导抑制因子1与调节性T淋巴细胞/辅助性T淋巴细胞17平衡的关系  

Role of signal transducer and activator of transcription 1 in regulation of Treg/Th17 balance in hepatocellular carcinoma

作　　者：宋瑞 李静 杨红菊[1] 李敏玥 游晶[1] SONG Rui;LI Jing;YANG Hongju;LI Minyue;YOU Jing(The NHC Key Laboratory of Drug Addiction Medicine,Department of Geriatric Gastroenterology,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China;School of Public Health,Kunming Medical University,Kunming 650500,China)

机构地区：[1]国家卫健委毒品依赖和戒治重点实验室,昆明医科大学第一附属医院老年消化内科,昆明650032 [2]昆明医科大学公共卫生学院,昆明650500

出　　处：《临床肝胆病杂志》2022年第11期2627-2631,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81760111,81760617);国家卫生健康委员会毒品依赖和戒治重点实验室科学研究A类重点项目(2020DAMARA-003)。

摘　　要：调节性T淋巴细胞(Treg)和辅助性T淋巴细胞17(Th17)在肝细胞癌(HCC)的肿瘤微环境中发挥重要作用,Treg/Th17失衡与HCC的侵袭和进展密切相关。同时,细胞因子信号传导抑制因子1(SOCS1)作为Janus激酶/信号转导和转录激活因子信号通路的负调控因子之一,参与调控Treg细胞和Th17细胞的增殖、分化。本文主要分析HCC中SOCS1与Treg/Th17平衡的关系,探究HCC发生发展过程中的免疫相关机制。The regulatory T cells(Treg)and helper T cells 17(Th17)play an important role in regulation of the tumor microenvironment in hepatocellular carcinoma(HCC)because Treg/Th17 imbalance was associated with HCC cell invasion and progression.Moreover,the suppressor of cytokine signaling 1(SOCS1),a negative regulator of the Janus kinase(JAK)/signal transducers and activators of transcription(STAT)pathway,regulates Treg and Th17 proliferation and differentiation.This review summarized and discussed the recent advancement and progress in control of the Treg/Th17 balance in HCC and the immunity-related mechanisms in HCC development and progression,i.e.,the SOCS1 structure and functions,SOCS1 role in regulation of Treg/Th17 balance in HCC,and future research direction of the field.

关 键 词：癌 肝细胞 细胞因子类 信号传导 T淋巴细胞 调节性 T淋巴细胞 辅助诱导 

分 类 号：R735.7[医药卫生—肿瘤]