高脂血症性急性胰腺炎的临床特征及其甘油三酯水平对预后及并发症的影响  

Clinical Features of Hyperlipidemic Acute Pancreatitis and Effect of Triglyceride Level on Prognosis and Complications

作　　者：魏怡敏 郭建强[2] WEI Yi-min;GUO Jian-qiang(Cheeloo College of Medicine,Shandong University,Jinan 250012,Shandong,China;Department of Gastroenterology,the Second Hospital of Shandong University,Jinan 250033,Shandong,China)

机构地区：[1]山东大学齐鲁医学院,山东济南250012 [2]山东大学第二医院消化内科,山东济南250033

出　　处：《医学信息》2022年第19期51-53,共3页Journal of Medical Information

摘　　要：目的探究高脂血症性急性胰腺炎的临床特征及入院甘油三酯(TG)对其预后和并发症的影响。方法选取2018年1月-2021年6月于山东大学第二医院住院的263例急性胰腺炎患者为研究对象,按照病因分为高脂血症组(HLAP组)67例,非高脂血症组(非HLAP组)196例,比较两组一般资料及实验室指标。随后根据入院24h TG水平将HLAP组患者分为两组,其中轻度TG组(5.65 mmol/L≤TG<11.3 mmol/L)41例,重度TG组(TG≥11.3 mmol/L)26例,分析不同水平TG对HLAP预后及并发症的影响。结果HLAP组男性、糖尿病、脂肪肝占比均高于非HLAP组,空腹血糖、TG、CRP、Hct、血尿酸水平均高于非HLAP组,差异有统计学意义(P<0.05);HLAP组年龄、血淀粉酶水平、高血压占比低于非HLAP组,差异有统计学意义(P<0.05);入院24h重度TG组ICU入住率、胰腺坏死、SIRS、急性胰周积液、急性肝损伤发生率高于轻度TG组,差异有统计学意义(P<0.05)。结论HLAP患者以青年男性为主,易合并糖尿病、脂肪肝及高尿酸血症,并发SIRS,具有重症化倾向,且入院24h内TG≥11.3 mmol/L容易合并多种并发症。Objective To investigate the clinical characteristics of hyperlipidemic acute pancreatitis and the effect of triglyceride(TG)on its prognosis and complications.Methods A total of 263 patients with acute pancreatitis who were hospitalized in the Second Hospital of Shandong University from January 2018 to June 2021 were selected as the research objects.According to the etiology,they were divided into hyperlipidemia group(HLAP group)67 cases and non-hyperlipidemia group(non-HLAP group)196 cases.The general data and laboratory indicators of the two groups were compared.According to the level of TG at 24 h after admission,the patients in the HLAP group were divided into two groups,including 41 cases in the mild TG group(5.65 mmol/L≤TG<11.3 mmol/L)and 26 cases in the severe TG group(TG≥11.3 mmol/L).The effects of different levels of TG on the prognosis and complications of HLAP were analyzed.Results The proportion of male,diabetes and fatty liver in the HLAP group was higher than that in the non-HLAP group,and the levels of fasting blood glucose,TG,CRP,Hct and blood uric acid were higher than those in the non-HLAP group(P<0.05).The age,blood amylase level and proportion of hypertension in HLAP group were lower than those in non-HLAP group,and the differences were statistically significant(P<0.05).The incidence of ICU admission,pancreatic necrosis,SIRS,acute peripancreatic effusion and acute liver injury in the severe TG group was higher than that in the mild TG group at 24 hours after admission,and the difference was statistically significant(P<0.05).Conclusion HLAP patients are mainly young men,and are prone to diabetes,fatty liver and hyperuricemia,complicated with SIRS,with a tendency to be severe,and TG≥11.3 mmol/L within 24 hours of admission is prone to multiple complications.

关 键 词：急性胰腺炎 高脂血症 甘油三酯 

分 类 号：R576[医药卫生—消化系统]