去甲肾上腺素与凝血酶冻干粉内镜下喷洒的止血效果比较  

Comparison of Hemostatic Effects of Norepinephrine and Lyophilizing Thrombin Powder SprayedUnder Endoscopy

作　　者：黄玲 张传彬 钟鸣 HUANG Ling;ZHANG Chuan-bin;ZHONG Ming(Department of Gastroenterology,Shangyou County People's Hospital,Shangyou 341200,Jiangxi,China)

机构地区：[1]上犹县人民医院消化内科,江西上犹341200

出　　处：《医学信息》2022年第19期130-132,共3页Journal of Medical Information

摘　　要：目的比较去甲肾上腺素与凝血酶冻干粉内镜下喷洒的止血效果。方法选取2019年1月-2021年6月我院诊治的72例消化道出血患者为研究对象,采用随机数字表法分为对照组和观察组,各36例。对照组在内镜下喷洒去甲肾上腺素治疗,观察组在内镜下喷洒凝血酶冻干粉治疗,比较两组临床疗效、止血时间、潜血转阴时间、72 h再出血率、凝血功能指标[血浆凝血酶原时间(PT)、活化部分凝血活酶原时间(APTT)、纤维蛋白原(Fbg)]以及不良反应发生情况。结果观察组治疗总有效率为94.44%,高于对照组的83.33%(P<0.05);观察组止血时间、潜血转阴时间均短于对照组(P<0.05);观察组72 h再出血率为5.56%,低于对照组的19.44%(P<0.05);观察组PT、APTT短于对照组,Fbg高于对照组(P<0.05);观察组不良反应发生率为8.33%,低于对照组的19.44%(P<0.05)。结论去甲肾上腺素与凝血酶冻干粉内镜下喷洒均具有一定的止血效果,但凝血酶冻干粉治疗效果更优,可降低72 h再出血率,缩短止血和潜血转阴时间,促进凝血功能恢复,且不良反应少。Objective To compare the hemostatic effects of norepinephrine and lyophilizing thrombin powder under endoscopy.Methods A total of 72 patients with gastrointestinal bleeding diagnosed and treated in our hospital from January 2019 to June 2021 were selected as the study subjects.They were divided into control group and observation group by random number table method,with 36 cases in each group.The control group was treated with endoscopic spraying of norepinephrine,and the observation group was treated with endoscopic spraying of lyophilizing thrombin powder.The clinical efficacy,hemostasis time,occult blood negative conversion time,72 h rebleeding rate,coagulation function indexes[plasma prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fbg)]and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.44%,which was higher than 83.33%in the control group(P<0.05).The hemostasis time and occult blood negative time in the observation group were shorter than those in the control group(P<0.05).The rebleeding rate at 72 h in the observation group was 5.56%,which was lower than 19.44%in the control group(P<0.05).PT and APTT in the observation group were shorter than those in the control group,and Fbg was higher than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was 8.33%,which was lower than 19.44%in the control group(P<0.05).Conclusion Norepinephrine and lyophilizing thrombin powder for endoscopic spraying have certain hemostatic effect,but lyophilizing thrombin powder has better therapeutic effect,which can reduce the 72 h rebleeding rate,shorten the time of hemostasis and occult blood negative conversion,promote the recovery of coagulation function,and have fewer adverse reactions.

关 键 词：去甲肾上腺素 凝血酶冻干粉 内镜 止血效果 

分 类 号：R573.2[医药卫生—消化系统]