中医药调控JAK2-STAT3信号通路治疗阿尔茨海默病研究进展  

Research progress in the regulation of the JAK2-STAT3 signaling pathway by traditional Chinese medicine in the treatment of Alzheimer’s disease

作　　者：毕淑月 张立娟[2] 管秀菊 侯翰如 李明襄 王康锋[2] BI Shuyue;ZHANG Lijuan;GUAN Xiuju;HOU Hanru;LI Mingxiang;WANG Kangfeng(Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]山东中医药大学附属医院脑病三科,山东济南250014

出　　处：《陕西中医》2022年第11期1643-1646,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金资助项目(81303028);济南市科技发展计划项目(202019027,202134007);山东省中医药科技发展计划项目(2019-0107,2019-0094);山东省科技发展计划项目(2014GSF119038);山东中医药大学附属医院首批青年科研创新团队项目。

摘　　要：阿尔茨海默病(AD)又称老年性痴呆,是临床较常见的慢性进行性中枢神经系统变性疾病之一,也是老年痴呆最常见的类型。AD的病因复杂,治疗药物匮乏,其发病机制与治疗靶点始终是国内外研究的热点问题。近年来,在中医药治疗AD的研究中,JAK2-STAT3信号通路已被多项研究证实与AD的进展密切相关。研究发现多种中药复方与中药有效成分可作用于此信号通路,通过调控Aβ的异常表达、Tau蛋白过磷酸化、神经细胞炎症反应等方面减轻和改善AD患者临床症状。现对近年来国内外中医药调控JAK2-STAT3信号通路在阿尔茨海默病的作用机制及有关治疗进行综述,以期为中医药深入治疗AD提供研究靶点和参考思路。Alzheimer’s disease(AD),also known as senile dementia,is one of the most common chronic progressive central nervous system degenerations and the most common type of dementia in old age.The etiology of AD is complex and the treatment drugs are scarce.The pathogenesis and therapeutic targets of AD have always been a hot issue in domestic and foreign research.In recent years,the JAK2-STAT3 signaling pathway has been confirmed to be closely related to the progress of AD by many studies in the treatment of AD with traditional Chinese medicine.Studies have found that a variety of traditional Chinese medicine compounds and effective components of traditional Chinese medicine can act on this signaling pathway,by regulating the abnormal expression of Aβ,Tau protein hyperphosphorylation,nerve cell inflammation,and other aspects to reduce and improve the clinical symptoms of AD patients.This paper reviews the mechanism and treatment of traditional Chinese medicine regulating the JAK2-STAT3 signaling pathway in Alzheimer’s disease in recent years,in order to provide research targets and reference ideas for the in-depth treatment of AD by traditional Chinese medicine.

关 键 词：阿尔茨海默病 酪氨酸激酶-信号转导子与转录激活子 Aβ异常表达 TAU蛋白 神经炎症 突触功能障碍 

分 类 号：R749.1[医药卫生—神经病学与精神病学]