肝豆状核变性患者血清超氧化物歧化酶活性水平变化及与年龄、病程、尿酸和24 h尿铜的相关性  

Analysis of serum superoxide dismutase activity and its correlation with age,duration of disease,uric acid and 24-hour urine copper in patients with hepatolenticular degeneration

作　　者：夏昆 韩永升 艾文龙 王玉 朱玉龙 孙丹丹 付晓明 叶群荣 李凯 杨任民 XIA Kun;HAN Yong-sheng;AI Wen-long(Institute of Neurology,Anhui University of Traditional Chinese Medicine,Hefei 230031,China;Anhui Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Hefei 230031,China)

机构地区：[1]安徽中医药大学神经病学研究所,安徽合肥230061 [2]安徽省中西医结合医院,安徽合肥230031

出　　处：《吉林医学》2022年第11期2928-2933,共6页Jilin Medical Journal

摘　　要：目的:观察肝豆状核变性(HLD)患者血清超氧化物歧化酶(SOD)活性水平的变化特点,并分析血清SOD活性水平与患者年龄、病程、尿酸和24 h尿铜的相关性。方法:回顾性分析500例HLD住院患者,参照2015年杨任民等制定的HLD分型标准,对入组患者的性别、年龄、病程、临床分型、肝脏分型和临床分级进行分类与统计,并统计患者驱铜治疗前血清SOD活性水平、尿酸(UA)水平、驱铜治疗前24 h尿铜(疗前24 h尿铜)和二巯基丙磺酸钠驱铜治疗第1个疗程第2天的24 h尿铜(疗后24 h尿铜),分析并比较不同性别、年龄、病程、临床分型、肝脏分型和临床分级的HLD患者血清SOD活性水平差异,同时分析血清SOD活性水平与患者年龄、病程、UA、疗前24 h尿铜和疗后24 h尿铜的相关性。结果:500例HLD患者中,25例血清SOD活性降低,136例血清SOD活性升高,总异常率为32.2%。男、女性别间的血清SOD活性水平比较,差异无统计学意义(P>0.05)。不同年龄分组、病程分组、临床分型、肝脏分型、临床分级的HLD患者的血清SOD活性水平差异具有统计学意义(P<0.05)。其中,年龄分组1~10岁组患者血清SOD活性水平最高,51~60岁组患者最低;病程分组6~10年组患者血清SOD活性水平最高,21~30年组患者最低;临床分型症状前期型患者血清SOD活性水平最高,脑-内脏型患者最低;肝脏分型轻微病变型患者血清SOD活性水平最高,结节型患者最低,患者血清SOD活性水平随着肝脏损伤程度的加重,呈逐渐下降趋势;临床分级0级患者血清SOD活性水平最高,Ⅳ级患者最低,患者血清SOD活性水平随着临床分级等级的升高,呈逐渐下降趋势。HLD患者血清SOD活性水平与年龄、病程及24 h尿铜之间成负相关关系,差异有统计学意义(P<0.05),与UA之间成正向相关关系,差异有统计学意义(P<0.05)。结论:HLD患者存在血清SOD活性水平的异常变化,血清SOD活性水平与患者年龄、病�Objective To observe the changes of serum superoxide dismutase(SOD)activity in patients with hepatolenticular degeneration(HLD),and to analyze the correlation of SOD activity with age,duration of disease,uric acid and 24h urine copper.Method A retrospective analysis of 500 inpatients with HLD who were hospitalized.Referring to the HLD classification standard formulated by Yang Renmin et al in 2015,the gender,age,duration of disease,clinical classification,liver classification and clinical grade of the enrolled patients were counted.In addition,the serum SOD activity level,uric acid(UA)level and 24-hour urinary copper of the enrolled patients before copper complexation treatment,as well as the 24-hour urinary copper on the second day of the first course of treatment with sodium dimercaptopropanesulfonate.The differences in serum SOD activity levels of HLD patients with different gender,age,duration of disease,clinical classification,liver classification and clinical grade were analyzed and compared,and their correlation with serum SOD activity levels of patients was also analyzed.Results Among the 500 HLD patients,25 had decreased serum SOD activity levels,and 136 had elevated serum SOD activity levels,with a total abnormal rate of 32.2%.There was no significant difference in serum SOD activity levels between males andfemales(P>0.05).There were significant differences in serum SOD activity levels among HLD patients with different age groups,duration of disease groups,clinical classification,liver classification and clinical grades(P<0.05).Among them,the serum SOD activity level of patients in the age group of 1-10 years was the highest,while that in the age group of 51-60 years was the lowest;the serum SOD activity level was the highest in patients with a course of 6-10 years,and the lowest in patients with a course of 21-30 years;the serum SOD activity levels were highest in patients with presymptomatic type,and lowest in patients with brain-visceral type;the level of serum SOD activity in patients with mild live

关 键 词：肝豆状核变性 血清超氧化物歧化酶 尿酸 24 h尿铜 

分 类 号：R742.4[医药卫生—神经病学与精神病学]