PGⅠ、PGⅡ联合CA19-9、CA724在慢性萎缩性胃炎中的诊断价值  

Diagnostic value of PGⅠand PGⅡcombined with CA19-9 and CA724 in chronic atrophic gastritis

作　　者：苏利国 程森连 李海婷 SU Li-guo;CHENG Sen-lian;LI Hai-ting(Comprehensive Department of internal medicine,Qingyuan maternal and child health hospital of Guangdong Province,Qingyuan 511500,China;Endoscopy Center of Qingyuan Maternal and child health hospital of Guangdong Povince,Qingyuan 511500,China)

机构地区：[1]清远市妇幼保健院综合内科,广东清远511500 [2]清远市妇幼保健院内镜中心,广东清远511500

出　　处：《吉林医学》2022年第11期3045-3048,共4页Jilin Medical Journal

基　　金：清远市科技计划项目[项目编号:201924]。

摘　　要：目的:探讨血清胃蛋白酶原Ⅰ(PGⅠ)、血清胃蛋白酶原Ⅱ(PGⅡ)联合糖抗原19-9(CA19-9)、糖抗原724(CA724)在慢性萎缩性胃炎中的诊断价值。方法:选取清远市妇幼保健院疑似胃炎就诊并经胃镜及病理组织学检查确诊的60例慢性萎缩性胃炎患者为萎缩性胃炎组(轻度组18例,中度组31例,重度组11例);50例浅表性胃炎患者为浅表性胃炎组;40例最终排除胃部疾病者为对照组。采用乳胶增强免疫比浊法定量检测患者血清PGⅠ、PGⅡ水平并计算PGR(PGⅠ/PGⅡ),电化学发光免疫分析法检测血清CA19-9、CA724水平。比较各组各血清指标水平差异并采用受试者工作特征(ROC)曲线评价各指标单独及联合检测对慢性萎缩性胃炎的诊断价值。结果:慢性萎缩性胃炎血清PGⅠ及PGR水平均低于浅表性胃炎组和对照组,PGⅡ、CA19-9、CA724水平均高于浅表性胃炎组和对照组,差异均有统计学意义(P<0.05);浅表性胃炎组患者血清PGⅠ、PGⅡ、CA19-9、CA724及PGR水平与对照组比较,差异无统计学意义(P>0.05)。胃黏膜萎缩程度越重,PGⅠ、PGR水平越低,PGⅡ、CA19-9及CA724水平越高,差异均有统计学意义(P<0.05)。5项血清指标联合检测对慢性萎缩性胃炎的诊断曲线下面积为0.931,敏感性为79.31%,特异性为83.52%,敏感性和曲线下面积均高于5项血清指标单独检测的诊断价值。结论:各血清指标联合检测能明显提高慢性萎缩性胃炎的诊断价值,高于单一血清指标检测,有利于早期诊断并根治慢性萎缩性胃炎以降低胃癌发生率。Objective To investigate the diagnostic value of serum pepsinogenⅠ(PGⅠ),serum pepsinogenⅡ(PGⅡ)combined with sugar antigen 19-9(CA19-9)and sugar antigen 724(CA724)in chronic atrophic gastritis.Method Sixty patients with chronic atrophic gastritis who were diagnosed with gastritis and histopathological examination in our hospital were selected as the atrophic gastritis group(mild group 18 cases,severe group 31 Cases,11 cases in severe group);50 cases of superficial gastritis patients were in the superficial gastritis group;40 cases who finally ruled out stomach diseases were the control group.Latex-enhanced immunoturbidimetry was used to quantitatively detect serum PGⅠand PGⅡlevels and calculate PGR(PGⅠ/PGⅡ),electrochemiluminescence immunoassay was used to detect serum CA19-9 levels,and chemiluminescence was used to detect serum CA724 levels.The differences in the levels of various indexes in each group were compared and the receiver operating characteristic curve(ROC)was used to evaluate the diagnostic value of individual indexes and combined detection of chronic atrophic gastritis.Results The levels of serum PGⅠand PGR in atrophic gastritis were lower than those in superficial gastritis group and control group,while the levels of PGⅡ,CA19-9 and CA724 were higher than those in superficial gastritis group and control group,the differences were statistically significant(P<0.05);The serum PGⅠ,PGⅡ,CA19-9,CA724 and PGR levels in patients with superficial gastritis were compared with the control group(P>0.05).The more severe the gastric atrophy,the lower the levels of PGⅠand PGR,and the higher the levels of PGⅡ,CA19-9 and CA724(P<0.05).The combined detection of five serum indexes for the diagnosis of chronic atrophic gastritis has an area under the curve of 0.931,a sensitivity of 79.31%,and a specificity of 83.52%.Both the sensitivity and the area under the curve are higher than the diagnostic value of the five serum indexes alone.Conclusion The combined detection of five serum indexes can si

关 键 词：慢性萎缩性胃炎 血清胃蛋白酶原Ⅰ 血清胃蛋白酶原Ⅱ 糖抗原19-9 糖抗原724 诊断价值 

分 类 号：R573.32[医药卫生—消化系统]