加味泻黄散联合盐酸硫必利片治疗儿童多发性抽动症(脾胃积热证)的临床疗效观察  

Observation of the clinical efficacy of modified Xiehuang powder combined with tiapride hydrochloride tablets in the treatment of children with multiple tics(syndrome of heat accumulation in spleen and stomach)

作　　者：陈厚杨 CHEN Hou-yang(Department of Pediatrics,Youxi County Hospital of Traditional Chinese Medicine,Sanming 365100,China)

机构地区：[1]福建省三明市尤溪县中医院儿科,365100

出　　处：《中国现代药物应用》2022年第19期30-33,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 探讨加味泻黄散联合盐酸硫必利片对儿童多发性抽动症(脾胃积热证)的临床疗效。方法 100例儿童多发性抽动症(脾胃积热证)患儿,采用随机数字表法分为治疗组与对照组,每组50例。治疗组采用加味泻黄散联合盐酸硫必利片治疗,对照组采用盐酸硫必利片治疗。对比两组患儿的西医临床效果、中医证候疗效、治疗前后的中医症状评分,观察用药安全性。结果 治疗组患儿的西医临床总有效率为92%,高于对照组的76%,差异具有统计学意义(P<0.05)。治疗组患儿的中医证候总有效率为88%,高于对照组的64%,差异具有统计学意义(P<0.05)。治疗前,两组患儿的口干口臭、食欲不振、烦躁易怒、大便秘结、小便黄赤评分对比,差异无统计学意义(P>0.05);治疗后,治疗组患儿的口干口臭、食欲不振、烦躁易怒、大便秘结、小便黄赤评分分别为(1.0±0.4)、(1.1±0.3)、(1.3±0.4)、(1.6±0.6)、(1.5±0.4)分,均低于对照组的(1.8±0.5)、(2.0±0.4)、(2.2±0.2)、(2.5±0.4)、(2.2±0.6)分,差异具有统计学意义(P<0.05)。治疗过程中两组患儿进行血尿大便常规,结果并未出现异常,对照组患儿发生1例嗜睡,减少药物用量后症状缓解。结论 儿童多发性抽动症(脾胃积热证)选择加味泻黄散联合盐酸硫必利片进行治疗效果确切,可改善患儿的临床症状,且用药具有安全可靠性。Objective To discuss the clinical efficacy of modified Xiehuang powder combined with tiapride hydrochloride tablets in the treatment of children with multiple tics(heat accumulation in spleen and stomach).Methods A total of 100 children with multiple tics(syndrome of heat accumulation in spleen and stomach)were divided into treatment group and control group by random numerical table,with 50 cases in each group.The treatment group was treated with modified Xiehuang powder combined with tiapride hydrochloride tablets,and the control group was treated with tiapride hydrochloride tablets.The clinical efficacy of western medicine,efficacy of traditional Chinese medicine syndromes,and the traditional Chinese medicine symptom score before and after treatment were compared between the two groups,and the safety of medication was observed.Results The total clinical efficacy rate of western medicine in the treatment group was 92%,which was higher than 76%in the control group,and the difference was statistically significant(P<0.05).The total effective rate of traditional Chinese medicine syndromes in the treatment group was 88%,which was higher than 64%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the scores of dry mouth and bad breath,loss of appetite,irritability,constipation and yellow urine between the two groups(P>0.05).After treatment,the scores of dry mouth and bad breath,loss of appetite,irritability,constipation and yellow urine in the treatment group were(1.0±0.4),(1.1±0.3),(1.3±0.4),and(1.6±0.6)and(1.5±0.4)points,which were lower than(1.8±0.5),(2.0±0.4),(2.2±0.2),(2.5±0.4)and(2.2±0.6)points in the control group,and the differences were all statistically significant(P<0.05).During the treatment,blood,urine and stool routine was performed in both groups,and the results did not show any abnormalities.1 case of drowsiness occurred in the control group,and the symptoms were relieved after reducing the drug do

关 键 词：盐酸硫必利片 加味泻黄散 多发性抽动症 脾胃积热证 

分 类 号：R749.94[医药卫生—神经病学与精神病学]