姜黄素类化合物的研究进展  

Research progress of curcuminoids

作　　者：刘宗易 彭明利[1] LIU Zongyi;PENG Mingli(Key Laboratory of Molecular Biology for Infectious Diseases,Institute for Viral Hepatitis,Department of Infectious Diseases,The Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学感染性疾病分子生物学教育部重点实验室,重庆医科大学病毒性肝炎研究所,重庆医科大学附属第二医院感染科,重庆400010

出　　处：《药学研究》2022年第10期673-677,共5页Journal of Pharmaceutical Research

基　　金：国家科技重大专项(No.2018ZX10302206-003)。

摘　　要：姜黄素作为中药姜黄的主要活性成分,对炎症、肿瘤、代谢类疾病和神经系统疾病均显示良好的应用前景,因其生物利用度低限制了临床应用。围绕姜黄素的结构修饰一直是药物学家的兴趣所在。本文就近五年姜黄素类化合物研究进展进行综述,为开发姜黄素类药物提供参考。Curcumin,as the main active component of the traditional Chinese medicine turmeric,shows good application prospects for inflammation,tumors,metabolic diseases and neurological diseases,and its clinical application is limited due to its low bioavailability.The structural modification around curcumin has always been of interest to pharmacologists.This article reviews the research progress of curcuminoids in the past five years,and provided references for the development of curcumin drugs.

关 键 词：姜黄素类化合物 结构修饰 药理活性 构效关系 生物利用度 

分 类 号：R284.3[医药卫生—中药学]