3,5-二氯苯甲酸的合成  

Synthesis of signal molecular intermediate 3,5-dichlorobenzoic acid

作　　者：袁勇军[1] 丁钰涵 陈秋平[1] 杨华[1] 曾礼 YUAN Yongjun;DING Yuhan;CHEN Qiuping;YANG Hua;ZENG Li(School of Zhejiang Wanli University,Ningbo,Zhejiang 315100,China;School of Dalian University,Dalian,Liaoning,116622,China;School of Nanchang University,Nanchang 330031,China)

机构地区：[1]浙江万里学院,浙江宁波315100 [2]大连大学医学院,辽宁大连116622 [3]南昌大学化学学院,江西南昌330031

出　　处：《南昌大学学报（理科版）》2022年第5期543-549,共7页Journal of Nanchang University(Natural Science)

基　　金：浙江省自然科学基金资助项目(LY17C010001);浙江省基础公益技术应用研究计划(LGN22D060003)。

摘　　要：3,5-二氯苯甲酸,在诸多领域有着广泛的应用。但传统的合成方法复杂,原料昂贵。本文介绍了一种新的合成路线,即以2-硝基苯甲酸为原料,先合成邻氨基苯甲酸,经单因素条件优化本步骤收率可达88.7%,再合成2-氨基-3,5-二氯苯甲酸,经正交优化本步骤收率可达84.3%,最后合成3,5-二氯苯甲酸,经响应曲面法优化本步骤收率可达92%,因此该路线总收率可达到68%以上。与传统的合成方法相比,该合成方法原料丰富易得,溶剂可回收利用,产生三废较少,适于工业化生产。The 3,5-dichlorobenzoic acid has been widely used in many fields.But the traditional synthesis method is complicated and the raw materials are expensive.In this paper,with 2-nitrobenzoic acid as raw materials,a new synthetic route was designed to synthetize o-aminobenzoic acid which has an optimal ratio of yield(88.7%)under the single factor conditions.In the second step,the 2-amino-3,5-dichlorobenzoic acid was synthetized and its optimal ratio of yield can reach 84.3%via the orthogonal optimizing procedure.Lastly,the 3,5-dichlorobenzoic acid was synthetized and the response surface method was utilized to obtain an optimal yield ratio 92%.Therefore,the overall yield ratio in this route can reach more than 68%.Compared with the traditional synthesis method,this synthesis method is suitable for industrial production because the raw materials are abundant and easy to obtain;also the solvent can be recycled and reused,with less three-waste being produced.

关 键 词：2-硝基苯甲酸 邻氨基苯甲酸 2-氨基-3 5-二氯苯甲酸 3 5-二氯苯甲酸 

分 类 号：O625.52[理学—有机化学]