Are CD45RO^(+)and CD45RA^(-)genuine markers for bovine memory T cells?  

作　　者：Kandel Anmol Hada Akanksha Xiao Zhengguo 

机构地区：[1]Department of Animal and Avian Sciences,Universityof Maryland,College Park,MD 20742,USA

出　　处：《Animal Diseases》2022年第4期213-221,共9页动物疾病（英文）

基　　金：supported by USDA NIFA Grant 2016-67015-24948(to ZX);Grant 2019-67015-29831(to ZX);the Jorgensen Foundation(to ZX);MAES program in University of Maryland(to ZX).

摘　　要：Effective vaccination in duces memory T cells,which protect the host against pathogen re-infecti ons.Therefore,detection of memory T cells is essential for evaluating vaccine efficacy,which was originally dependent on cytokine induction assays.Currently,two isoforms of CD45 tyrosine phosphatase,CD45RO expression and CD45RA exclusion(CD45RO^(+)/CD45RA^(-)) are used extensively for detecting memory T cells in cattle.The CD45RO^(+)/CD45RA^(-) markers were first established in humans around three decades ago,and were adopted in cattle soon after.However,in the last two decades,some published data in humans have challenged the initial paradigm,and required multiple markers for identifying memoryT cells.On the contrary,memoryT cell detection in cattle still mostly relies on CD45RO^(+)/CD45RA^(-)despite some con troversial evidence.In this review,we summarized the current literature to exami ne if CD45RO^(+)/CD45RA^(-)are valid markers for detecting memoryT cells in cattle.It seems CD45RA and CD45RO(CD45RA/RO)as markers for identifyi ng bovine memoryT cells are questi on able.

关 键 词：CATTLE Memory MARKERS T cells CD45RO CD45RA Vaccines Cytokines 

分 类 号：S852.4[农业科学—基础兽医学]