基于生物信息学分析S100P基因在乳腺癌中的表达及临床意义  

Analysis of S100P Gene Expression and Clinical Significance in Breast Cancer Based on Bioinformatics

作　　者：许康 白丽 Xu Kang;Bai Li(Pre-clinical College,Dali University,Dali,Yunnan 671000,China;Yunnan Key Laboratory for Biomedicine Research and Development,Dali,Yunnan 671000,China)

机构地区：[1]大理大学基础医学院,云南大理671000 [2]云南省昆虫生物医药研发重点实验室,云南大理671000

出　　处：《大理大学学报》2022年第10期68-74,共7页Journal of Dali University

基　　金：国家自然科学基金项目(81360319);云南省中药饮片产业发展专项资金项目(2019-YG-067)。

摘　　要：目的:探讨S100P基因在乳腺癌中的表达及临床意义。方法:使用多种在线生物信息学数据库分析S100P的分子表达、调控网络及预后价值。结果:S100P基因在乳腺癌中的表达水平明显高于正常组织(P<0.05);S100P表达水平与乳腺癌淋巴结转移相关(P<0.05),且高表达水平与较差的预后有关(P<0.001);S100P主要参与糖基化、粒细胞活化等生物学过程,并与蛋白酶体、白细胞介素-17等信号通路相关。结论:S100P在乳腺癌中高表达,是乳腺癌诊断、治疗和预后的潜在靶点。Objective:To investigate the expression and clinical significance of S100P gene in breast cancer. Methods:A variety of online bioinformatics databases were used to analyze the molecular expression,regulatory network and prognostic value of S100P.Results:The expression level of S100P gene in breast cancer was significantly higher than that in normal tissues(P<0.05). S100P expression was correlated with lymph node metastasis in breast cancer(P<0.05),and high expression level was associated with poor prognosis(P<0.001). S100P was mainly involved in biological processes such as glycosylation and granulocyte activation,and was related to proteasome,IL-17 and other signal pathways. Conclusion:High expression of S100P in breast cancer is a potential target for diagnosis,treatment and prognosis of breast cancer.

关 键 词：乳腺癌 S100P 生物信息学分析 

分 类 号：R737.9[医药卫生—肿瘤]