烟酰胺腺嘌呤二核苷酸(NAD+)在眼科疾病发生发展过程中的作用  

The role of nicotinamide adenine dinucleotide in the progression of ophthalmic diseases

作　　者：刘茜 陈培培 丁雪萌 汪颖[1] 许祎[1] 管怀进[1] LIU Xi;CHEN Peipei;DING Xuemeng;WANG Ying;XU Yi;GUAN Huaijin(Eye Institute,Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China)

机构地区：[1]南通大学附属医院眼科研究所,江苏省南通市226001

出　　处：《眼科新进展》2022年第11期906-909,共4页Recent Advances in Ophthalmology

基　　金：国家重点研发计划项目(编号:2017YFA0701304);国家自然科学基金项目(82171038);江苏省研究生科研与实践创新计划项目(编号:KYCX19_2076)。

摘　　要：烟酰胺腺嘌呤二核苷酸(NAD+)是存在于所有活细胞中的必需吡啶核苷酸。NAD+长期代谢失衡会破坏机体的生理功能,包括涉及关键代谢途径的DNA修复基因的表达、次级信使信号传递和免疫调节。NAD+在眼科很多疾病的发生、发展及转归中扮演重要的角色,如角膜疾病、青光眼、先天性黑矇、年龄相关性黄斑变性、糖尿病视网膜病变等。本文就NAD+在眼科疾病发生发展过程中的作用进行综述,为眼科疾病的病理机制研究及治疗提供思路。Nicotinamide adenine dinucleotide(NAD+)is an essential pyridine nucleotide residing in all living cells.Long-term metabolic imbalances in NAD+can disrupt the body’s physiological functions,including the expression of DNA repair genes involved in key metabolic pathways,secondary messenger signalling,and immune regulation.NAD+plays an important role in the occurrence,progression and prognosis of many ophthalmic diseases,such as corneal disease,glaucoma,Leber congenital amaurosis,age-related macular degeneration,and diabetic retinopathy.This article reviews the role of NAD+in the progression of ophthalmic diseases to provide new ideas for the pathogenesis and treatment of ophthalmic diseases.

关 键 词：烟酰胺腺嘌呤二核苷酸 眼科疾病 青光眼 糖尿病视网膜病变 

分 类 号：R771[医药卫生—眼科]