胃癌患者外周血NLR水平、预后营养指数与临床病理特征的关系  

The Relationship between Peripheral Blood NLR Level,Prognostic Nutritional Index and Clinicopathological Characteristics in Gastric Cancer Patients

作　　者：杜云辉 万里新[1] 屈中玉[1] 刘越[1] 孙星 刘扬帆[1] 盛晶[1] DU Yun-hui;WAN Li-xin;QU Zhong-yu;LIU Yue;SUN Xing;LIU Yang-fan;SHENG Jing(Department of Oncology,Nanyang Central Hospital,Nanyang 473000,Henan Province,China)

机构地区：[1]南阳市中心医院肿瘤内科,河南南阳473000

出　　处：《罕少疾病杂志》2022年第11期67-69,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨胃癌患者外周血中性粒细胞/淋巴细胞比值(NLR)水平、预后营养指数(OPNI)与临床病理特征的关系,以期为临床诊治和评估胃癌患者病情严重程度提供参考依据。方法收集2019年10月至2021年6月本院收治的70例胃癌患者的临床资料,根据患者OPNI水平进行分组,OPNI=血清白蛋白水平(g/L)+5×外周血淋巴细胞总数(×109/L),再将患者分为高PNI组(PNI≥40)和低PNI组(PNI<40);根据NLR水平将患者为高NLR组(NLR≥4)和低NLR组(NLR<4)。比较高PNI组和低PNI组、高NLR组和低NLR组患者的一般资料及实验室资料。结果胃癌患者术前PNI与肿瘤直径、TNM分期、神经侵犯、CA125、CA199具有相关性(P<0.05)。与高PNI组患者相比较,低PNI组患者肿瘤直径较大、TNM分期较晚、神经侵犯较多、CA125升高、CA199升高(P<0.05),其余临床病理特征资料比较无统计学差别(P>0.05)。胃癌患者术前NLR与TNM分期具有相关性(P<0.05)。与低NLR组患者相比较,高NLR组患者TNM分期较晚(P<0.05)。其余临床病理特征资料比较无统计学差别(P>0.05)。结论胃癌患者外周血NLR水平、PNI均与患者TNM分期存在密切关联,提示可能用于评估胃癌患者预后。Objective To investigate the relationship between peripheral blood neutrophil/lymphocyte ratio(NLR)level,prognostic nutritional index(OPNI)and clinicopathological characteristics in patients with gastric cancer,in order to provide reference for clinical diagnosis and treatment and assessment of the severity of gastric cancer patients.Methods The clinical data of 70 gastric cancer patients admitted to our hospital from October 2019 to June 2021 were collected,and the patients were grouped according to their OPNI levels,OPNI=serum albumin level(g/L)+5×total number of peripheral blood lymphocytes(×109/L),and then divided the patients into high PNI group(PNI≥40)and low PNI group(PNI<40);according to the NLR level,patients were divided into high NLR group(NLR≥4)and low NLR group(NLR<4).The general data and laboratory data of patients in high PNI group and low PNI group,high NLR group and low NLR group were compared.Results The preoperative PNI of gastric cancer patients was correlated with tumor diameter,TNM stage,nerve invasion,CA125 and CA199(P<0.05).Compared with the patients in the high PNI group,the patients in the low PNI group had larger tumor diameter,later TNM staging,more nerve invasion,increased CA125 and CA199(P<0.05),and there was no statistical difference in other clinicopathological characteristics.(P>0.05).There was a correlation between preoperative NLR and TNM staging in gastric cancer patients(P<0.05).Compared with the patients in the low NLR group,the patients in the high NLR group had a later TNM stage(P<0.05).There was no statistical difference in other clinicopathological characteristics(P>0.05).Conclusion The levels of NLR and PNI in peripheral blood of patients with gastric cancer are closely related to the TNM stage of patients,suggesting that they may be used to evaluate the prognosis of patients with gastric cancer.

关 键 词：胃癌 中性粒细胞/淋巴细胞比值 预后营养指数 临床病理特征 

分 类 号：R735.2[医药卫生—肿瘤]