皮肤鳞状细胞癌73例血清膜联蛋白A2的表达水平及与预后的关系  

Expression of serum annexin A2 in patients with cutaneous squamous cell carcinoma and its relationship with prognosis

作　　者：黄友光 HUANG Youguang(Laboratory Department,Jining Skin Disease Prevention and Control Hospital,Jining,Shandong 272007,China)

机构地区：[1]济宁市皮肤病防治院检验科,山东济宁272007

出　　处：《安徽医药》2022年第12期2452-2455,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的 探究皮肤鳞状细胞癌(CSCC)病人血清膜联蛋白A2的表达水平及与预后的关系。方法 回顾性分析2011年10月至2014年3月济宁市皮肤病防治院收治的CSCC病人73例为(CSCC组)研究对象,根据随访结果分为预后良好组(n=54)和预后不良组(n=19),另取同期门诊健康体检者血清标本80例为对照组,采用酶联免疫吸附测定(ELISA)检测血清膜联蛋白A2水平,Cox分析影响CSCC病人不良结局的危险因素。结果 CSCC病人血清膜联蛋白A2(64.78±6.23)μg/L水平显著高于对照组(16.45±5.64)μg/L(P<0.05)。血清膜联蛋白A2水平与CSCC病人年龄、性别、发病部位、原发灶相比差异无统计学意义(P>0.05),与淋巴结转移、分化程度、侵犯深度有关(P<0.05)。预后不良组CSCC病人血清膜联蛋白A2(69.67±10.62)μg/L水平显著高于预后良好组(60.09±10.25)μg/L(P<0.05)。Cox多因素分析发现,淋巴结转移、侵犯深度及血清膜联蛋白A2水平高是影响CSCC病人预后的独立危险因素[HR=2.547、2.726、3.520;95%CI:(1.518,3.274)、(2.035,3.652)、(1.701,7.284),均P<0.001]。结论 血清膜联蛋白A2水平表达上调可能与CSCC病人淋巴结转移、分化程度、侵犯深度有关,推测膜联蛋白A2是影响CSCC病人不良预后的危险因素。Objective To investigate the relationship between the expression of Annexin A2 in serum and prognosis of patients with cutaneous squamous cell carcinoma(CSCC).Methods A retrospective analysis was conducted.A total of 73 CSCC patients admitted to Jining Dermatology Hospital from October 2011 to March 2014 were selected as the research object(CSCC group).According to the follow-up results,the patients were divided into good prognosis group(n=54) and poor prognosis group(n=19).Another 80 serum samples from healthy outpatients at the same time were taken as the control group.The serum Annexin A2 level was detected by enzymelinked immunosorbent assay(ELISA),and Cox was used to analyze the risk factors of adverse outcomes in CSCC patients.Results The serum Annexin A2(64.78±6.23) μg/L level of CSCC patients was significantly higher than that of the control group(16.45±5.64) μg/L(P<0.05).Serum Annexin A2 level was not related to age,gender,disease site and primary tumor of CSCC patients(P>0.05),but was related to lymph node metastasis,degree of differentiation and depth of invasion(P<0.05).The serum Annexin A2(69.67±10.62) μg/L level in CSCC patients in poor prognosis group was significantly higher than that in the good prognosis group(60.09±10.25) μg/L(P<0.05).Cox multivariate analysis showed that lymph node metastasis,depth of invasion and high serum Annexin A2 level were independent risk factors for the prognosis of CSCC patients [HR=2.547,2.726,3.520;95%CI:(1.518,3.274),(2.035,3.652),(1.701,7.284),all P<0.001].Conclusions The up-regulated expression of serum Annexin A2 level may be related to lymph node metastasis,degree of differentiation and depth of invasion in CSCC patients.It is speculated that Annexin A2 is a risk factor affecting the poor prognosis of CSCC patients.

关 键 词：皮肤肿瘤 癌 鳞状细胞 膜联蛋白A2 血清 预后 

分 类 号：R739.5[医药卫生—肿瘤]