食管肿瘤厚度联合中性粒细胞与淋巴细胞比值在诊断术前食管癌T4分期的临床价值  

Clinical value of esophageal tumor thickness combined with neutrophil to lymphocyte ratio in the diagnosis of preoperative T4 stage of esophageal cancer

作　　者：李婷婷 Li Tingting(Department of Radiation Therapy,The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000)

机构地区：[1]福建医科大学附属第二医院肿瘤放射治疗科,泉州362000

出　　处：《数理医药学杂志》2022年第11期1595-1597,共3页Journal of Mathematical Medicine

摘　　要：目的:探讨CT测量食管肿瘤厚度联合中性粒细胞与淋巴细胞比值(NLR)对诊断食管鳞癌术前T4分期的预测价值。方法:全组361例食管鳞癌患者均术前行抽血及胸部CT检查,并行根治性手术切除。受试者操作特征曲线(ROC)检测食管肿瘤厚度、NLR、血小板与淋巴结细胞比值(PLR)对诊断食管鳞癌T4分期的预测价值。结果:单因素分析显示脉管癌栓、食管肿瘤厚度、NLR、PLR对诊断术前食管鳞癌T4分期影响较大(P<0.005)。多因素分析显示食管肿瘤厚度、NLR为诊断T4食管鳞癌独立预测因子。T4组食管鳞癌患者的食管肿瘤厚度、NLR均较T1-3组食管鳞癌患者高(P<0.005)。食管肿瘤厚度、NLR与食管鳞癌分期呈正相关。食管肿瘤厚度联合NLR诊断T4食管鳞癌的ROC曲线下面积(AUC)为0.873。结论:食管肿瘤厚度联合NLR对诊断T4食管鳞癌具有较高的预测价值,可作为术前诊断食管鳞癌T4分期的的评估指标。Objective: To investigate the predictive value of CT measurement of esophageal tumor thickness combined with neutrophil to lymphocyte ratio(NLR) in the diagnosis of preoperative T4 staging of esophageal squamous cell carcinoma(ESCC). Methods: A total of 361 patients with esophageal squamous cell carcinoma underwent preoperative blood drawing and chest CT examination, and underwent radical resection. Receiver operating characteristic curve(ROC) was used to detect the predictive value of esophageal tumor thickness, NLR, platelet to lymph node cell ratio(PLR) in the diagnosis of T4 stage of esophageal squamous cell carcinoma. Results: Univariate analysis showed that vascular tumor thrombus, esophageal tumor thickness, NLR and PLR had significant influence on T4 stage of esophageal squamous cell carcinoma before diagnosis(P<0.005). Multivariate analysis showed that esophageal tumor thickness and NLR were independent predictors of T4 esophageal squamous cell carcinoma. Esophageal tumor thickness and NLR in patients with ESCC in T4 group were higher than those in patients with ESCC in T1-3 group(P<0.005). Esophageal tumor thickness and NLR are positively correlated with esophageal squamous cell carcinoma stage. The area under the ROC curve(AUC) of esophageal tumor thickness combined with NLR in the diagnosis of T4 esophageal squamous cell carcinoma was 0.873. Conclusion: Esophageal tumor thickness combined with NLR has a high predictive value for the diagnosis of T4 esophageal squamous cell carcinoma, which can be used as an evaluation index for the preoperative diagnosis of T4 stage of esophageal squamous cell carcinoma.

关 键 词：食管肿瘤厚度 中性粒细胞与淋巴细胞比值 受试者操作特征曲线 T分期 

分 类 号：R735.1[医药卫生—肿瘤]