血清铁蛋白与子痫前期及妊娠结局的相关性  

CORRELATION OF SERUM FERRITIN WITH PREECLAMPSIA AND PREGNANCY OUTCOME

作　　者：郑富民 卢彩霞[1] 高群[1] 王慧[1] 刘世国[2] 詹瑛[1] ZHENG Fumin;LU Caixia;GAO Qun;WANG Hui;LIU Shiguo;ZHAN Ying(Department of Obstetrics and Gynecology,The Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院妇产科,山东青岛266003 [2]青岛大学附属医院产前诊断中心,山东青岛266003

出　　处：《青岛大学学报（医学版）》2022年第5期747-750,共4页Journal of Qingdao University(Medical Sciences)

基　　金：山东省自然科学基金面上项目(ZR2019MH127)。

摘　　要：目的分析血清铁蛋白(SF)与子痫前期(PE)及妊娠结局的相关性,探讨SF水平对PE严重程度的评估价值。方法通过医渡云大数据系统,选取2018年12月—2021年6月于我院产科分娩的孕妇239例,根据有无PE分为PE组(95例)和对照组(144例),PE组根据病情严重程度分为轻度组(43例)和重度组(52例)。对孕妇临床检验指标、妊娠并发症及妊娠结局进行组间比较,并分析SF与妊娠并发症及妊娠结局的相关性。结果PE组SF水平明显高于对照组(t=-5.533,P<0.05),重度组SF水平明显高于轻度组(t=-3.322,P<0.05),而且发生早产、小于胎龄儿的孕妇SF水平明显高于未发生者(t=-3.701、-3.254,P<0.05)。Spearman相关分析显示,SF水平与PE严重程度呈正相关(ρ=0.453,P<0.001),与产后出血、早产、小于胎龄儿、胎盘早剥的发生也存在明显相关性(ρ=0.155~0.334,P<0.05)。结论孕妇SF水平与PE发病及妊娠结局相关,对PE的严重程度有一定评估价值。Objective To investigate the correlation of serum ferritin(SF)with preeclampsia(PE)and pregnancy outcome and the value of SF level in evaluating the severity of PE.Methods Based on the Yidu Cloud big data system,239 pregnant women who delivered in Department of Obstetrics in our hospital from December 2018 to June 2021 were enrolled,and according to the presence or absence of PE,they were divided into PE group with 95 patients and control group with 144 patients;according to disease severity,the PE group was further divided into mild group with 43 patients and severe group with 52 patients.Related clinical indicators,pregnancy complications,and pregnancy outcome were compared between groups,and the correlation of SF with pregnancy complications and pregnancy outcome was analyzed.Results The PE group had a significantly higher SF le-vel than the control group(t=-5.533,P<0.05),the severe group had a significantly higher SF level than the mild group(t=-3.322,P<0.05),and the pregnant women with premature delivery and small-for-gestational-age infants had a significantly hig-her SF level than those without these events(t=-3.701,-3.254;P<0.05).The Spearman correlation analysis showed that SF level was positively correlated with the severity of PE(ρ=0.453,P<0.001),and SF level was also significantly correlated with postpartum hemorrhage,premature delivery,small-for-gestational-age infants,and placental abruption(ρ=0.155-0.334,P<0.05).Conclusion SF level in pregnant women is associated with the onset of PE and pregnancy outcome and has a certain value in evaluating the severity of PE.

关 键 词：铁蛋白质类 先兆子痫 妊娠结局 

分 类 号：R714.244[医药卫生—妇产科学]