超声弹性成像技术联合Mts1蛋白诊断甲状腺癌的价值分析  

The Value of Ultrasound Elastography Combined with Mts1 Protein in the Diagnosis of Thyroid Cancer

作　　者：高洁 彭月享 赵珊珊 罗篪 高卫元 GAO Jie;PENG Yuexiang;ZHAO Shanshan;LUO Chi;GAO Weiyuan(Department of Ultrasound,Wuhan Wuchang Hospital,Wuhan 430063,Hubei,P.R.China;Department of Ultrasound,Wuhan Third Hospital(Tongren Hospital of Wuhan University),Wuhan 430074,Hubei,P.R.China)

机构地区：[1]武汉市武昌医院超声科,湖北武汉430063 [2]武汉市第三医院/武汉大学附属同仁医院超声科,湖北武汉430074

出　　处：《影像科学与光化学》2022年第6期1460-1464,共5页Imaging Science and Photochemistry

基　　金：武汉市卫健委科研项目(WX13D10)。

摘　　要：本研究旨在阐明超声弹性成像(UE)技术联合S100钙结合蛋白A4(Mts1/S100A4)诊断甲状腺癌(TC)及其淋巴结转移的价值。选择接受UE检查的甲状腺病变患者为研究对象,其中,107例患者(107个病灶)确诊为TC,纳入TC组,101例患者(101个病灶)确诊为甲状腺良性结节,纳入良性组。107例TC患者中64例未发生淋巴结转移,43例发生淋巴结转移。所有患者均接受了UE检查,使用人Mts1酶联免疫吸附测定(ELISA)试剂盒检测血清Mts1。结果显示,与良性组比较,TC组的SR和血清Mts1均升高(P<0.001)。相关性分析显示,SR和血清Mts1水平显著正相关(r=0.463,P<0.001)。SR和血清Mts1联合诊断TC的曲线下面积(AUC)(0.859)、敏感性(68.18%)和特异性(97.37%)均高于单独诊断。与未转移组比较,转移组的SR和血清Mts1均升高(P<0.01)。SR和血清Mts1联合诊断淋巴结转移的AUC(0.817)和特异性(89.06%)均高于单独诊断,但敏感性(65.12%)低于血清Mts1。SR联合血清Mts1的方案在诊断TC及淋巴结转移中具有较高的价值,可能有助于TC患者的早期诊断及淋巴结转移的预测。This study aimed to clarify the value of ultrasound elastography(UE)combined with S100 calcium binding protein A4(Mts1/S100A4)protein in the diagnosis of thyroid cancer(TC)and its lymph node metastasis.Patients with thyroid lesions who underwent UE examination in our hospital were selected as the research objects.Among them,107 patients(107 lesions)diagnosed with TC were included in the TC group,and 101 patients(101 lesions)diagnosed with benign thyroid nodules were included in the benign group.Among 107 patients with TC,64 patients did not develop lymph node metastasis and 43 patients developed lymph node metastasis.All patients underwent UE examination,and serum Mts1 was detected using human Mts1 enzyme-linked immunosorbent assay(ELISA)kit.The results showed that compared with the benign group,the SR and serum Mts1 in the TC group were increased(P<0.001).Correlation analysis showed that SR and serum Mts1 levels were significantly positively correlated(r=0.463,P<0.001).The area under the curve(AUC)(0.859),the sensitivity(68.18%)and the specificity(97.37%)of SR and serum Mts1 for diagnosing TC were higher than those for single diagnosis.Compared with the non-metastatic group,both SR and serum Mts1 in the metastatic group were increased(P<0.01).The combined AUC(0.817)and specificity(89.06%)of SR and serum Mts1 for the diagnosis of lymph node metastases were higher than those for single diagnosis,but the sensitivity(65.12%)was lower than that of serum Mts1.This study shows that SR combined with serum Mts1 is of high value in the diagnosis of TC and lymph node metastasis,and may be helpful for early diagnosis and prediction of lymph node metastasis in patients with TC.

关 键 词：超声弹性成像 MTS1 甲状腺癌 诊断 淋巴结转移 

分 类 号：R736.1[医药卫生—肿瘤] R445.1[医药卫生—临床医学]