MRI在AD患者诊断及病情程度评估中的应用  

Application of MRI in the Diagnosis and Severity Evaluation of AD Patients

作　　者：李玺琳[1] 张伟[1] 章邱东[1] LI Xilin;ZHANG Wei;ZHANG Qiudong(Department of Geriatrics,Fuyang People’s Hospital,Fuyang 236000,Anhui,P.R.China)

机构地区：[1]阜阳市人民医院老年医学科,安徽阜阳236000

出　　处：《影像科学与光化学》2022年第6期1529-1533,共5页Imaging Science and Photochemistry

摘　　要：本研究探讨磁共振成像(MRI)检查脑叶体积变化、脑白质疏松程度在诊断阿尔茨海默病(AD)患者及病情评估中的应用价值。选取确诊的90例AD患者为AD组、另外选取同期接受健康体检的90例志愿者作为对照组,两组研究对象均接受MRI检查,对比各项指标及脑白质疏松(LA)严重度分级差异,分析各项指标在诊断AD患者中的价值;并根据临床痴呆评定量表(CDR)将患者分为轻中度、重度,进行分层对比。AD组患者顶叶、枕叶及颞叶体积比例小于对照组(P<0.05);AD组患者的海马高度测定值小于对照组(P<0.05);AD组与对照组的LA分级情况比较,差异具有统计学意义(P<0.05);重度AD患者的顶叶体积比例、枕叶体积比例、颞叶体积比例、海马高度值小于轻中度AD患者(P<0.05);重度AD组患者LA分级以2级、3级为主,轻中度AD患者主要为0级、1级患者为主,重度AD组与轻中度AD患者的LA分级比较,差异具有统计学意义(P<0.05)。AD患者的脑叶体积、海马高度均发生变化,脑白质疏松变化较为明显,临床上采用MRI进行检查评估具有一定的价值。This study explored the application value of magnetic resonance imaging(MRI)examination of lobe volume changes and leukoaraiosis in the diagnosis of Alzheimer's disease(AD)patients and disease assessment.A total of 90 diagnosed AD patients were selected as the AD group,and 90 volunteers who received physical examinations during the same period were selected as the control group.Both groups underwent MRI examination,and the differences in various indicators and leukoaraiosis(LA)severity grading were compared.The value of each index in the diagnosis of AD patients were analyzed.According to the Clinical Dementia Rating Scale(CDR),the patients were divided into mild,moderate and severe for stratified comparison.The proportion of parietal,occipital and temporal lobe volume in the AD group was smaller than that in the control group(P<0.05).The measured value of hippocampal height in the AD group was lower than that in the control group(P<0.05).There was statistically significant difference in LA grade between the AD group and the control group(P<0.05).The proportion of parietal lobe volume,the proportion of occipital lobe volume,the proportion of temporal lob volume and hippocampal height in patients with severe AD were lower than those in patients with mild to moderate AD(P<0.05)in the severe AD group.The LA grades of the patients were mainly grade 2 and grade 3,and the patients with mild to moderate AD were mainly grade 0 and grade 1 patients.There was a statistically significant difference in LA grade between the severe AD group and the mild to moderate AD patients(P<0.05).The lobe volume and hippocampal height of AD patients all changed,and the changes in leukoaraiosis were more obvious.The clinical evaluation of MRI has a certain value.

关 键 词：磁共振成像 脑叶体积 脑白质疏松 阿尔茨海默病 诊断 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]