能谱CT联合长链非编码RNA UCA1在诊断胃腺癌淋巴结转移中的应用  

Application of Spectral CT Combined with Long Non-coding RNA UCA1 in the Diagnosis of Lymph Node Metastasis of Gastric Adenocarcinoma

作　　者：张健 任晓燕[2] ZHANG Jian;REN Xiaoyan(Department of Pain,Nantong Haimen People’s Hospital,Nantong 226113,Jiangsu,P.R.China;Department of Pathology,Affiliated Maternity and Child Health Care Hospital of Nantong University,Nantong 226007,Jiangsu,P.R.China)

机构地区：[1]南通市海门区人民医院疼痛科,江苏南通226113 [2]南通大学附属妇幼保健院病理科,江苏南通226007

出　　处：《影像科学与光化学》2022年第6期1539-1544,共6页Imaging Science and Photochemistry

摘　　要：本研究探讨能谱CT参数联合长链非编码RNA(lncRNA)尿路上皮癌相关基因1(UCA1)诊断胃腺癌淋巴结转移的价值。选择103例胃腺癌患者为研究对象,均进行能谱CT检查,获得动脉期标准化碘浓度值(NICAP)和静脉期标准化碘浓度值(NICVP)。通过RT-PCR检测胃腺癌患者的血清UCA1水平。结果显示,转移组的NICAP和NICVP均显著高于非转移组患者(P<0.001)。分别以NICAP>0.132和NICVP>0.431为截断值,NICAP诊断淋巴结转移的AUC、敏感性和特异性分别为0.742、68.52%和76.09%,NICVP诊断淋巴结转移的AUC、敏感性和特异性分别为0.932、85.19%和86.96%。转移组患者的血清UCA1相对表达量显著高于非转移组患者的(P<0.001)。以血清UCA1相对表达量>2.071为截断值,血清UCA1诊断淋巴结转移的AUC、敏感性和特异性分别为0.884、87.04%和82.61%。NICAP+NICVP+UCA1联合诊断淋巴结转移的AUC、敏感性和特异性分别为0.985、94.44%和100.00%。能谱CT参数(NICAP和NICVP)联合血清UCA1在诊断胃腺癌淋巴结转移方面具有较高价值。This study investigated the value of spectral CT parameters combined with long non-coding RNA(lncRNA)urothelial carcinoma-associated gene 1(UCA1)in the diagnosis of lymph node metastasis in gastric adenocarcinoma.A total of 103 patients with gastric adenocarcinoma were selected as the research objects.All patients underwent spectral CT examination to obtain the normalized iodine concentration value in the arterial phase(NICAP)and the normalized iodine concentration value in the venous phase(NICVP).Serum UCA1 levels in patients with gastric adenocarcinoma were detected by RT-PCR.The results showed that NICAP and NICVP in the metastatic group were significantly higher than those in the non-metastatic group(P<0.001).Taking NICAP>0.132 and NICVP>0.431 as cutoff values,the AUC,sensitivity and specificity of NICAP and NICVP for the diagnosis of lymph node metastasis were(0.742,68.52%and 76.09%)and(0.932,85.19%and 86.96%),respectively.The relative expression of serum UCA1 in the metastatic group was significantly higher than that in the non-metastatic group(P<0.001).Taking the relative expression of serum UCA1>2.071 as the cut-off value,the AUC,sensitivity and specificity of serum UCA1 in the diagnosis of lymph node metastasis were 0.884,87.04%and 82.61%,respectively.The AUC,sensitivity and specificity of NICAP+NICVP+UCA1 in the diagnosis of lymph node metastasis were 0.985,94.44%and 100.00%,respectively.Spectral CT parameters(NICAP and NICVP)combined with serum UCA1 have high value in the diagnosis of lymph node metastasis of gastric adenocarcinoma.

关 键 词：能谱CT 胃腺癌 淋巴结转移 动脉期标准化碘浓度值 静脉期标准化碘浓度值 尿路上皮癌相关基因1 

分 类 号：R735.2[医药卫生—肿瘤] R730.44[医药卫生—临床医学]