Can DKI-MRI predict recurrence and invasion of peritumoral zone of hepatocellular carcinoma after transcatheter arterial chemoembolization?  

作　　者：Xin Cao Hao Shi Wei-Qiang Dou Xin-Yao Zhao Ying-Xin Zheng Ya-Ping Ge Hai-Chao Cheng Dao-Ying Geng Jun-Ying Wang 

机构地区：[1]Department of Medical Imaging,The First Affiliated Hospital of Shandong First Medical University&Shandong Province Qianfoshan Hospital,Jinan 250014,Shandong Province,China [2]Department of Radiology,Huashan Hospital,Fudan University,Shanghai 200040,China [3]Center for Shanghai Intelligent Imaging for Critical Brain Diseases Engineering and Technology Research,Shanghai 200040,China [4]MR Research,GE Healthcare,Beijing 10076,China [5]Department of Radiology,Yantaishan Hospital,Yantai 264001,Shandong Province,China [6]Department of Magnetic Resonance Imaging,Zhangqiu District People's Hospital,Jinan 250200,Shandong Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2022年第10期1150-1160,共11页世界胃肠外科杂志（英文版）（电子版）

基　　金：the Greater Bay Area Institute of Precision Medicine,No.KCH2310094;Shanghai Sailing Program,No.22YF1405000;Research Startup Fund of Huashan Hospital Fudan University,No.2021QD035;and Clinical Research Plan of SHDC,No.SHDC2020CR3020A.

摘　　要：BACKGROUND Hepatocellular carcinoma(HCC)is a major cause of cancer-related mortality worldwide.Transcatheter arterial chemoembolization(TACE)has been performed as a palliative treatment for patients with HCC.However,HCC is easy to recur after TACE.Magnetic resonance imaging(MRI)has clinical potential in evaluating the TACE treatment effect for patients with liver cancer.However,traditional MRI has some limitations.AIM To explore the clinical potential of diffusion kurtosis imaging(DKI)in predicting recurrence and cellular invasion of the peritumoral liver zone of HCC after TACE.METHODSSeventy-six patients with 82 HCC nodules were recruited in this study and underwent DKI afterTACE. According to pathological examinations or the overall modified response evaluationcriteria in solid tumors (mRECIST) criterion, 48 and 34 nodules were divided into true progressionand pseudo-progression groups, respectively. The TACE-treated area, peritumoral liver zone, andfar-tumoral zone were evaluated on DKI-derived metric maps. Non-parametric U test and receiveroperating characteristic curve (ROC) analysis were used to evaluate the prediction performance ofeach DKI metric between the two groups. The independent t-test was used to compare each DKImetric between the peritumoral and far-tumoral zones of the true progression group.RESULTSDKI metrics, including mean diffusivity (MD), axial diffusivity (DA), radial diffusivity (DR), axialkurtosis (KA), and anisotropy fraction of kurtosis (Fak), showed statistically different valuesbetween the true progression and pseudo-progression groups (P < 0.05). Among these, MD, DA,and DR values were higher in pseudo-progression lesions than in true progression lesions,whereas KA and FAk values were higher in true progression lesions than in pseudo-progressionlesions. Moreover, for the true progression group, the peritumoral zone showed significantlydifferent DA, DR, KA, and FAk values from the far-tumoral zone. Furthermore, MD values of theliver parenchyma (peritumoral and far-tumoral zones) were

关 键 词：Diffusion kurtosis imaging Hepatocellular carcinoma Transcatheter arterial chemoembolization RECURRENCE 

分 类 号：R735.7[医药卫生—肿瘤]