胃泌素-17、菱形结构域蛋白1、幽门螺杆菌IgG抗体诊断胃癌的价值及与肿瘤浸润的关系  

Value of gastrin-17,RHBDD1,and Helicobacter pylori IgG antibody in diagnosis of gastric cancer and their relationship with tumor infiltration

作　　者：沈丽君 刘旭朋 施立煌 方丽琴 Li-Jun Shen;Xu-Peng Liu;Li-Huang Shi;Li-Qin Fang(Department of Laboratory Medicine,Hangzhou Ninth People’s Hospital,Hangzhou 311225,Zhejiang Province,China;Department of Laboratory Medicine,Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine,Hangzhou 310020,Zhejiang Province,China)

机构地区：[1]杭州市第九人民医院检验科,浙江省杭州市311225 [2]浙江大学医学院附属邵逸夫医院检验科,浙江省杭州市310020

出　　处：《世界华人消化杂志》2022年第20期914-920,共7页World Chinese Journal of Digestology

摘　　要：背景胃癌的发生是一个多步骤癌变的过程,涉及多方面因素,胃泌素-17(gastrin 17,G-17)、菱形结构域蛋白1(rhomboid domain-containing protein1,RHBDD1)、幽门螺杆菌(Helicobacter pylori,H.pylori)感染在胃癌形成过程中具有重要作用,或许能作为胃癌筛查及病情评估的标志物.目的探究血清G-17、RHBDD1、H.pylori免疫球蛋白G(immunoglobulin G,IgG)抗体(H.pylori-IgG)阳性率对胃癌与癌前病变的筛查价值及与肿瘤浸润深度关系.方法选取2021-01/2022-01我院85例胃癌患者作为研究组,根据1:1匹配病例对照原则选取同期85例胃癌前病变患者作为对照组,比较两组一般资料、血清G-17、RHBDD1水平及H.pylori-IgG阳性率,采用受试者工作特征(receiver operating characteristic,ROC)曲线评价血清G-17、RHBDD1水平、H.pylori-IgG阳性率诊断胃癌的价值,并比较不同肿瘤浸润深度胃癌患者血清G-17、RHBDD1水平、H.pylori-IgG阳性率,采用Spearman相关系数模型分析血清G-17、RHBDD1水平、H.pylori-IgG阳性率与胃癌肿瘤浸润深度的相关性,并分析血清G-17、RHBDD1水平、H.pylori-IgG阳性率对胃癌患者肿瘤浸润深度的影响.结果研究组血清G-17、RHBDD1水平及H.pylori-IgG阳性率均高于对照组(P<0.05);血清G-17、RHBDD1水平、H.pylori-IgG阳性联合诊断胃癌的曲线下面积(area under the curve,AUC)为0.915;血清G-17、RHBDD1水平、H.pylori-IgG阳性率随着胃癌患者肿瘤浸润深度增加呈逐渐升高趋势(P<0.05);血清G-17、RHBDD1水平、H.pylori-IgG阳性率与胃癌肿瘤浸润深度呈正相关(P<0.05);血清G-17高表达与RHBDD1高表达、G-17高表达与H.pylori-IgG阳性、RHBDD1高表达与H.pylori-IgG阳性均对胃癌患者肿瘤浸润深度呈次相乘模型的正向交互作用(P<0.05).结论血清G-17、RHBDD1、H.pylori-IgG联合检测有助于提高胃癌与癌前病变的筛查价值,且参与胃癌肿瘤浸润,与肿瘤浸润深度呈正相关.BACKGROUND The occurrence of gastric cancer is a multi-step process involving many factors.Gastrin-17(G-17),rhomboid domain-containing protein 1(RHBDD1),and Helicobacter pylori(H.pylori)infection play an important role in the development of gastric cancer and may be used as markers for gastric cancer screening and disease assessment.AIM To assess the value of serum G-17,RHBDD1,and H.pylori IgG antibody(H.pylori-IgG)in the screening of gastric cancer and precancerous lesions and to analyze their relationship with the depth of tumor infiltration.METHODS Eighty-five gastric cancer patients treated at our hospital from January 2021 to January 2022 were selected as a study group,and 85 patients with gastric precancerous lesions in the same period were selected as a control group according to the 1:1 matched case-control principle.The general data,serum G-17 and RHBDD1 levels,and H.pylori-IgG positive rate were compared between the two groups.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the value of serum G-17 and RHBDD1 levels and H.pylori-IgG positive rate in diagnosing gastric cancer.Serum G-17 and RHBDD1 levels and H.pylori-IgG positive rate were compared in gastric cancer patients with different tumor infiltration depth,and their correlation with and impact on tumor infiltration depth were analyzed using Spearman’s correlation coefficient.RESULTS Serum G-17 and RHBDD1 levels and H.pylori-IgG positive rate in the study group were significantly higher than those in the control group(P<0.05).The area under the curve(AUC)of the three indexes combined in the diagnosis of gastric cancer was 0.915.Serum G-17 and RHBDD1 levels and H.pylori-IgG positive rate increased with the increase in the depth of tumor infiltration in gastric cancer patients(P<0.05),and they were positively correlated with the depth of tumor infiltration(P<0.05).These three indexes and infiltration depth showed a positive interaction in a sub-phase multiplicative model(P<0.05).CONCLUSION Combined detection of serum

关 键 词：胃癌 癌前病变 胃泌素-17 菱形结构域蛋白1 幽门螺杆菌抗体 

分 类 号：R735.2[医药卫生—肿瘤]