短链脂肪酸调节肠黏膜屏障缓解炎性肠病新进展  

Insight into role of short chain fatty acids in regulating intestinal mucosal barrier and alleviating inflammatory bowel disease

作　　者：郭雪然 贺程威 高晗 华嵘暄 梁宸 杜奕萱 尚宏伟[3] 路欣[3] 徐敬东[2] Xue-Ran Guo;Cheng-Wei He;Han Gao;Rong-Xuan Hua;Chen Liang;Yi-Xuan Du;Hong-Wei Shang;Xin Lu;Jing-Dong Xu(School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China;Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China;Teaching Laboratory of Morphology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学,北京市100069 [2]首都医科大学基础医学院生理学与病理生理学系,北京市100069 [3]首都医科大学基础医学院形态学教学实验室,北京市100069

出　　处：《世界华人消化杂志》2022年第21期928-940,共13页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目,No.82174056和No.81673671;国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项课题,No.2016YFC1306305。

摘　　要：肠道微生物群在维持人体肠道内环境中的重要性被逐渐揭示,其代谢产物参与调节肠道多种生理学功能.短链脂肪酸(short-chain fatty acids,SCFAs)是肠道微生物群的代谢产物,不仅是肠上皮细胞(intestinal epithelialcells,IECs)的重要能量来源之一,而且通过不同机制调节肠上皮细胞增殖、分化,保护肠黏膜屏障的完整性和通透性,促进肠道粘液分泌的平衡与紧密连接表达的稳定性.炎症性肠病(inflammatory bowel disease,IBD)是一种特发性肠道炎症性疾病,发病率高引起广泛关注,以黏膜炎症与通透性改变为主要表现,但其病因和发病机制尚未完全明确.大量研究表明SCFAs对维持结肠的正常功能和结肠上皮细胞的形态和功能具有重要作用.本文就SCFAs通过调节肠黏膜屏障缓解IBD的作用最新研究进行综述,以期为临床治疗IBD提供新靶点.In recent years,the importance of intestinal microbiota and its metabolites in maintaining the human intestinal environment has been gradually revealed.Therefore,short chain fatty acids(SCFAs),as the metabolites produced by the intestinal microbiota,play a momentous part in regulating the balance between the function and morphology of the mucosal barrier,regulating the proliferation and differentiation of mucosal cells,protecting the integrity and permeability of the mucosal barrier,and maintainingthe stability of tight junctions.Inflammatory bowel disease(IBD) is a chronic,inflammatory condition of the gastrointestinal tract,associated with a disturbance of intestinal barrier function and dysregulation of the intestinal immune responses,the etiology and pathogenesis of which,however,are not yet fully uncovered.Animal models and human studies have corroborated the contribution of SCFAs in enhancing the barrier function through protective effects.This review will summarize the potential role of SCFAs in IBD with regard to regulating intestinal function,hoping to provide a new target for clinical treatment of IBD.

关 键 词：短链脂肪酸 肠黏膜屏障 肠上皮细胞 肠道菌群 炎症性肠病 

分 类 号：R574[医药卫生—消化系统]