Therapeutic applications of adipose-derived stromal vascular fractions in osteoarthritis  

作　　者：Qi Tang Xian-Sheng Zhao Ao Guo Ruo-Tong Cui Huai-Le Song Zi-Yang Qi Yi Pan Yue Yang Fang-FangZhang Liang Jin 

机构地区：[1]School of Life Science and Technology,China Pharmaceutical University,Nanjing 211198,Jiangsu Province,China [2]Department of Dermatology,Huashan Hospital,Fudan University,Shanghai 200040,China

出　　处：《World Journal of Stem Cells》2022年第10期744-755,共12页世界干细胞杂志（英文版）（电子版）

基　　金：Supported by National Natural Science Foundation of China,No.82070801,No.82100858,No.82073227;China Postdoctoral Science Foundation,No.2020M671661;Jiangsu Province Science Foundation for Youths,No.BK20200569;Jiangsu Province Research Founding for Postdoctoral,No.1412000016.

摘　　要：Osteoarthritis(OA)is considered to be a highly heterogeneous disease with progressive cartilage loss,subchondral bone remodeling,and low-grade inflammation.It is one of the world's leading causes of disability.Most conventional clinical treatments for OA are palliative drugs,which cannot fundamentally cure this disease.The stromal vascular fraction(SVF)from adipose tissues is a heterogeneous cell population.According to previous studies,it contains a large number of mesenchymal stem cells,which have been used to treat OA with good therapeutic results.This safe,simple,and effective therapy is expected to be applied and promoted in the future.In this paper,the detailed pathogenesis,diagnosis,and current clinical treatments for OA are introduced.Then,clinical studies and the therapeutic mechanism of SVF for the treatment of OA are summarized.

关 键 词：ARTHRITIS Articular cartilage Stromal vascular fraction Mesenchymal stem cells Cell therapy 

分 类 号：R684.3[医药卫生—骨科学]