Coxsackievirus A6 was the most common enterovirus serotype causing hand,foot,and mouth disease in Shiyan City,central China  

作　　者：Jing-Feng Li Chuan-Jie Zhang Ya-Wei Li Chao Li Shi-Chao Zhang Sha-Sha Wang Yong Jiang Xin-Bing Luo Xing-Juan Liao Shou-Xin Wu Ling Lin 

机构地区：[1]Department of Pediatrics,Taihe Hospital,Affiliated Hospital of Hubei University of Medicine,Shiyan 442000,Hubei Province,China [2]Department of Children Health Care,Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital),Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430061,Hubei Province,China [3]Department of Health Services,Taihe Hospital,Affiliated Hospital of Hubei University of Medicine,Shiyan 442000,Hubei Province,China [4]Department of Pharmaceuticals,Shanghai Biotecan Pharmaceuticals Co.Ltd.,Shanghai 200000,China [5]Zhangjiang Center for Translational Medicine,Shanghai Zhangjiang Institute of Medical Innovation,Shanghai 442000,China

出　　处：《World Journal of Clinical Cases》2022年第31期11358-11370,共13页世界临床病例杂志

基　　金：Supported by the Hubei Province Health and Family Planning A Scientific Research Project,No.WJ2017M220;the Wuhan Health Bureau Scientific Research Fund,No.WX19C11;the Joint Precision Medical Research Fund From Taihe Hospital,No.2016JZ10;the Shiyan COVID-19 Pilot Emergency Scientific Research Project,No.20Y19;the Wuhan Children's Hospital Research Project,No.2017FE007.

摘　　要：BACKGROUND Hand,foot,and mouth disease(HFMD)has become one of the most common infectious diseases in China.Before 2016,the primary causal serotypes were enterovirus A71(EV-A71)and coxsackievirus A16(CV-A16).Following the introduction of EV-A71 vaccines in China since 2016,the situation could change.CV-A6 has recently replaced EV-A71 and CV-A16 in some areas of China.However,the epidemiological characteristics of central China remain unknown.AIM To investigate the clinical symptoms and pathogen spectrum of HFMD in Shiyan City,central China,in recent years.METHODS The epidemiological,clinical,and laboratory data from HFMD cases reported to the Shiyan Center for Disease Control and Prevention between January 2016 and December 2020 were analyzed.196 throat swab specimens were collected from hospitalized HFMD patients between January 2018 and December 2020.To detect and genotype enteroviruses,real-time reverse transcription-polymerase chain reaction and sequencing of the 5'-untranslated region were used.In Shiyan,168 laboratory-confirmed HFMD cases were studied using a logistic regression model to determine the effect of predominant enterovirus serotypes.Based on the logistic regression model,the least absolute shrinkage and selection operator model was used to analyze the correlation between CV-A6 infection and various clinical characteristics in HFMD patients in Shiyan.RESULTS From 2016 to 2020,35840 HFMD cases were reported in Shiyan.The number of cases decreased by 48.4%from 2016 to 2017.Approximately 1.58-fold increases were found in 2018 and 2019 when compared to the previous year,respectively.In 2020,a decrease of about 85.5%was reported when compared to 2019.The most common serotypes shifted from EV-A71 and CV-A16(about 60%-80%in 2016 and 2018)to others(more than 80.0%in 2017,2019,and 2020).EV-A71 lost its dominance in 2017 in Shiyan.Among 196 confirmed HFMD cases,85.7%tested positive for enterovirus,with CV-A6 being the most common serotype(121/168,72.0%).The positive rates for CV-A16 and CVA10 were 4.8%and 3

关 键 词：Hand foot and mouth disease Coxsackievirus A6 ENTEROVIRUS Prevalence serotype Fever Myocardial damage 

分 类 号：R725.1[医药卫生—儿科]