氯氮平所致动眼危象1例  

Oculogyric crisis caused by clozapine:a case report

作　　者：邓鸿将 张岚[1] Deng Hongjiang;Zhang Lan(West China Hospital of Sichuan University,Chengdu 610040,China)

机构地区：[1]四川大学华西医院,四川成都610040

出　　处：《四川精神卫生》2022年第5期467-470,共4页Sichuan Mental Health

摘　　要：本文报告1例14岁精神分裂症女性患者,病程2余年,使用阿立哌唑、利培酮、奥氮平等非典型抗精神病药物后疗效差,且在服药过程中出现急性肌张力障碍。随后更换为氯氮平治疗,使用氯氮平治疗期间,患者精神病性症状好转,但出现了流涎以及氯氮平所致动眼危象、吐词不清、吞咽困难等不良反应。本文通过对该案例进行讨论,以期为临床医生对氯氮平所致动眼危象的识别和处理提供参考。This paper reported a case of a 14-year-old female patient with schizophrenia of more than 2 years who had poor efficacy on atypical antipsychotics such as aripiprazole,risperidone and olanzapine,and who developed acute dystonia adverse effects during administration.Subsequently,the treatment was changed to clozapine therapy,and during this treatment,the patient's psychotic symptoms improved,but developed salivation and adverse effects such as clozapine-induced oculogyric crisis,slurred speech and dysphagia.This paper discussed this case with a view to providing a reference for clinicians in the recognition and management of oculogyric crisis caused by clozapine.

关 键 词：精神分裂症 氯氮平 肌张力障碍 动眼危象 治疗性药物监测 

分 类 号：R749.3[医药卫生—神经病学与精神病学]