维生素D补充对抑郁症患者快感缺失的影响  

Effect of Vitamin D Supplementation on Anhedonia in Patients with Depressive Disorder

作　　者：谢添琹 张磊[2] 余家快 王婷[1] 张玉[1] 朱鹏[2] 朱道民 Xie Tianqin;Zhang Lei;Yu Jiakuai(Department of Sleep Disorders,Affiliated Psychological Hospital of Anhui Medical University,Anhui Mental Health Center,Hefei Fourth People′s Hospital,Hefei,Anhui 230000;Anhui Medical University,Hefei,Anhui 230032,China)

机构地区：[1]安徽医科大学附属心理医院·安徽省精神卫生中心·合肥市第四人民医院睡眠障碍科,安徽合肥230000 [2]安徽医科大学,安徽合肥230032

出　　处：《四川医学》2022年第10期962-967,共6页Sichuan Medical Journal

基　　金：合肥市卫计委应用医学研究项目(编号:hwk2018yb001)。

摘　　要：目的探讨维生素D补充对抑郁症患者快感缺失症状的影响。方法纳入2017年2月至2019年11月我院接诊的抑郁症患者148例,采用随机数字表法分为干预组(n=75)和对照组(n=73)。对照组进行常规抗抑郁药治疗。干预组在常规抗抑郁药治疗的基础上,额外给予维生素D滴剂1600 IU/d干预2个月。干预前后对所有受试者进行血清维生素D水平、社会快感缺失量表(RSAS)、躯体快感缺失量表(RPAS)、24项汉密尔顿抑郁量表(HAMD_(24))、汉密尔顿焦虑量表(HAMA)的测定与评估。结果基线时,两组RSAS、RPAS评分差异无统计学意义(均P>0.05)。干预2个月后,干预组的RSAS、RPAS评分显著低于对照组(均P<0.05),在调整混杂变量后,差异仍有统计学意义(均P<0.05)。分层分析显示,与基线时相比,研究结束时干预组基线维生素D缺乏[25(OH)D<50 nmol/L]患者的RSAS评分、RPAS评分显著降低,差异有统计学意义(均P<0.05),而干预组基线维生素D不足[50 nmol/L≤25(OH)D<75 nmol/L]患者的RSAS评分、RPAS评分干预前后差异无统计学意义(均P>0.05)。结论维生素D缺乏的抑郁症患者进行维生素D补充可显著改善患者的快感缺失症状。Objective To study effects of vitamin D on anhedonia in patients with depressive disorder.Methods From February 2017 to November 2019,148 patients with depressive disorder admitted to Heifei Fourth People s Hospital were randomly divided into control group(CG,n=73)and intervention group(IG,n=75).CG receive conventional antidepressant medication.IG received vitamin D drops 1600 IU/d on the basis.Before and after intervention,serum vitamin D levels,revised social anhedonia scale(RSAS),revised physical anhedonia scale(RPAS),Hamilton depression scale(HAMD_(24))and Hamilton Anxiety Rating Scale(HAMA)were assessed and recorded for all participants.Results There was no statistical difference in RSAS and RPAS scores between two groups when study began(all P>0.05).At the end of our study,great difference was shown between intervention group and control group(P<0.05),and difference was still significant after adjusting confounding factors(P<0.05).Compared with beginning of our study,RSAS and RPAS scores were much lower in vitamin D deficiency patients of intervention group(P<0.05).However,result wasn t found in patients with Vitamin D insufficiency of intervention group(P>0.05).Conclusion The use of vitamin D supplement may obviously moderate anhedonia symptom in vitamin D deficiency patients with depressive disorder.

关 键 词：维生素D 抑郁症 快感缺失 

分 类 号：R749.4[医药卫生—神经病学与精神病学]