胆红素在炎性肠病中作用的研究进展  

Research progress on the role of bilirubin in inflammatory bowel disease

作　　者：师丽 袁浩[2] 刘敏[2] 郑亚 王玉平[2] 郭庆红[2] SHI Li;YUAN Hao;LIU Min;ZHENG Ya;WANG Yu-ping;GUO Qing-hong(the First Clinical Medical School,Lanzhou University,Lanzhou 730030;Department of Gastroenterology,Key Laboratory of Gastrointestinal Diseases of Gansu Province,the First Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730030 [2]兰州大学第一医院消化科,甘肃省胃肠病重点实验室,甘肃兰州730030

出　　处：《基础医学与临床》2022年第12期1925-1929,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(81960430);甘肃省自然科学基金(21JR1RA117);兰州大学第一医院院内基金(ldyyyn2018-38,ldyyyn2018-54)。

摘　　要：胆红素在炎性肠病中的作用不仅仅局限于抗氧化、抗炎作用,还有免疫调节、抗血小板聚集、抑制消化蛋白酶、调节肠道菌群等作用。血清胆红素水平与疾病的活动性、严重程度相关,是炎性肠病潜在的血清标志物,有助于临床炎性肠病诊治。The role of bilirubin in inflammatory bowel disease is not only functioned as an antioxidant and anti-inflammatory factor,but also functioned in immune regulation,anti-platelet aggregation,and as inhibition factor of digestive protease and remodeling of microbiota.Serum bilirubin level is correlated with disease activity and severity,so is a potential serum marker of inflammatory bowel disease in terms of supporting clinical diagnosis and treatment of inflammatory bowel disease.

关 键 词：胆红素 炎性肠病 克罗恩病 溃疡性结肠炎 

分 类 号：R574.6[医药卫生—消化系统]