原发性干燥综合征相关性干眼的西医研究进展  

Western Medicine research progress of primary Sjögren's syndrome-related dry eye

作　　者：甘建平[1] 王晶[1] 张莹[1] 吴斌[1] GAN Jianping;WANG Jing;ZHANG Ying;WU Bin(Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400021,China)

机构地区：[1]重庆市中医院,重庆400021

出　　处：《中国中医眼科杂志》2022年第11期911-914,共4页China Journal of Chinese Ophthalmology

基　　金：重庆市技术创新与应用发展专项重点项目(cstc2019jscx-dxwtBX0023);重庆市科委绩效激励引导专项(cstc2018jxj1130016)。

摘　　要：原发性干燥综合征(pSS)是一种主要累及外分泌腺体,以眼干、口干为主要表现的系统性自身免疫性疾病,重则可出现肺间质纤维化伴感染、肺动脉高压、肾衰竭、中枢神经病变等系统损害。原发性干燥综合征相关型干眼(pSS-DED)的发病机制尚不明确,研究表明可能与遗传、感染和性激素水平等多种因素有关。目前,本病不能根治,也没有特效的治疗方法,西医治疗主要以缓解干眼症状为主。本文利用文献回顾分析其发病机制,并通过3个层次来阐述pSS-DED的治疗进展,包括使用泪液的替代治疗,从而改善干眼症状;通过增强泪腺的残余功能,刺激泪液的分泌;通过系统用药改变pSS的免疫病理过程,从而保护患者的泪腺和脏器功能。Primary Sjogren's Syndrome(pSS)is a systemic autoimmune disease that mainly affects exocrine glands,with dry eye and dry mouth as the main manifestations.In serious cases,it may lead to pulmonary interstitial fibrosis with infection,pulmonary hypertension,renal failure,cen⁃tral neuropathy,and other system damage.The pathogenesis of primary Sjogren's syndrome-related dry eye disease(pSS-DED)is still unclear,and studies have shown that it may be related to mul⁃tiple factors such as heredity,infection,and sex hormone levels.At present,there is no effective drug,let alone to be cured,instead,treatment mainly focused on relieving dry eye symptoms.This ar⁃ticle analyzes its pathogenesis by literature review and explains the progress of treatment through three levels:Improving dry eye symptoms by using tear replacement therapy;Stimulating the secre⁃tion of tears by enhancing the residual function of the lacrimal gland;Protecting the patient's lacri⁃mal gland and organ function by changing the immunopathological process of pSS through sys⁃temic medication.

关 键 词：原发性干燥综合征 原发性干燥综合征相关型干眼 研究进展 

分 类 号：R777.34[医药卫生—眼科]