p53及Survivin表达与食管癌患者胸腔镜下根治术后疗效的关系分析  

The Relationship Between the Expression Levels of p53,Survivin and the Curative Effect of Esophageal Cancer Patients After Thoracoscopic Radical Resection

作　　者：刘勤[1] 张卫国[1] 王新帅[1] LIU Qin;ZHANG Weiguo;WANG Xinshuai(The First Affiliated Hospital of Henan University of Saence and Technology,Luoyang,471000)

机构地区：[1]河南科技大学第一附属医院,471000

出　　处：《实用癌症杂志》2022年第11期1783-1786,1795,共5页The Practical Journal of Cancer

基　　金：河南省医学科技攻关项目(编号:2018010019)。

摘　　要：目的分析p53及Survivin表达水平与食管癌胸腔镜下根治术后疗效的关系。方法选取于胸腔镜下行根治术的食管癌患者150例作为观察对象。采用免疫组织化学法分析食管癌组织中p53及Survivin阳性表达率。采用Pearson相关性分析survivin和p53基因在食管癌组织中表达的相关性。Kaplan-Meier方法绘制患者的生存曲线。结果癌组织中survivin和p53阳性表达率明显高于癌旁组织(P<0.05)。高分化患者survivin阳性蛋白表达率高于低分化患者(P<0.05)。淋巴结转移者p53阳性蛋白表达率高于无淋巴结转移者(P<0.05)。远处转移患者survivin和p53阳性表达率高于无远处转移患者(P<0.05);复发患者survivin和p53阳性表达率高于非复发患者(P<0.05)。Pearson相关性分析结果显示,食管癌组织中survivin与p53表达呈正相关(γ=0.352,P<0.05)。survivin阳性表达患者3年生存率为48.60%,明显低于survivin阴性表达患者(62.79%)(P<0.05);p35阳性表达患者3年生存率为45.79%,明显低于p35阴性表达患者69.77%(P<0.05)。结论食管癌组织中survivin和p53阳性表达率明显升高,且其阳性表达与术后复发转移和生存率有关。Objective To analyze the relationship between p53,Survivin and curative effect after thoracoscopic radical resection of esophageal cancer.Methods A total of 150 patients with esophageal cancer who underwent thoracoscopic radical resection were selected as the observation objects.The positive expression rates of p53 and Survivin in esophageal cancer tissues were detected by immunohistochemistry.The correlation between survivin and p53 gene in esophageal cancer tissues was analyzed by Pearson correlation analysis.The survival curves of patients were drawn by Kaplan-Meier method.Results The positive expression rates of survivin and p53 in cancer tissues were significantly higher than those in para-cancerous tissues(P<0.05).The positive expression rate of survivin protein in patients with high differentiation was higher than that with low differentiation(P<0.05).The positive expression rate of p53 protein in patients with lymph node metastasis was higher than that without metastasis(P<0.05).The positive expression rates of survivin and p53 in patients with distant metastasis were higher than those without distant metastasis(P<0.05),which were higher in patients with recurrence than patients without recurrence(P<0.05).The results of Pearson correlation analysis showed that survivin was positively correlated with p53 in esophageal cancer tissues(γ=0.352,P<0.05).The 3-year survival rate in patients with positive survivin was significantly lower than that with negative survivin(48.60%vs 62.79%)(P<0.05),which was significantly lower in patients with positive p35 than negative p35(45.79%vs 69.77%)(P<0.05).Conclusion The positive expression rates of survivin and p53 in esophageal cancer tissues are significantly increased,and their positive expressions are related to postoperative recurrence,metastasis and survival rate.

关 键 词：食管癌 胸腔镜下根治术 P53 SURVIVIN 临床疗效 

分 类 号：R735.1[医药卫生—肿瘤]