pro-GRP和Napsin A在肺癌组织中的表达水平及与临床预后的关系  

Expression Levels of Pro-GRP and Napsin A in Patients with Lung Cancer and Their Relationship with Clinical Prognosis

作　　者：张文静 张光亮 苏亚丽 齐林 ZHANG Wenjing;ZHANG Guangliang;SU Yali(Pingmei Shenma Group General Hospital,Pingdingshan,467000)

机构地区：[1]中国平煤神马集团总医院,467000

出　　处：《实用癌症杂志》2022年第11期1796-1800,共5页The Practical Journal of Cancer

摘　　要：目的分析胃泌素释放肽前体(pro-GRP)和天冬氨酸肽酶A(Napsin A)在肺癌组织中的表达水平及与临床预后的关系。方法选择93例手术切除的肺癌癌组织标本及其相应的癌旁组织(距离肿瘤边缘5 cm以上的正常组织)标本,采用免疫组织化学染色法检测标本中pro-GRP和Napsin A表达水平,并分析二者表达水平与肺癌患者临床预后的关系。结果肺癌组pro-GRP阳性表达率显著高于对照组(P<0.05),Napsin A阳性表达率显著低于对照组(P<0.05)。pro-GRP阳性表达与肺癌患者肿瘤大小、临床分期、分化程度以及淋巴结转移有关(P<0.05),Napsin A阳性表达与肺癌病理类型、临床分期、分化程度以及淋巴结转移有关(P<0.05)。随访3年,死亡组pro-GRP阳性表达率显著高于生存组(P<0.05),Napsin A阳性表达率显著低于生存组(P<0.05)。多因素Cox风险回归分析显示,分化程度(γ=1.955,95%CI:1.313~2.916,P=0.002)、淋巴结转移(γ=2.584,95%CI:1.509~4.407,P=0.001)、pro-GRP表达水平(γ=1.581,95%CI:0.872~2.653,P<0.001)、Napsin A表达水平(γ=2.063,95%CI:1.429~2.989,P<0.001)是影响肺癌患者临床预后的独立因素。结论肺癌组织中pro-GRP表达水平上调,Napsin A表达水平下调,且二者表达水平与患者临床预后存在密切关联,有可能作为肺癌潜在的治疗靶点以及临床预后预测因子。Objective To analyze the expression levels of progastrin-releasing peptide(pro-GRP)and aspartic peptidase A(Napsin A)in patients with lung cancer and their relationship with clinical prognosis.Methods The surgically resected cancer tissue specimens and their corresponding paracancerous tissues(normal tissue more than 5 cm from the tumor edge)of 93 patients with lung cancer were selected.Immunohistochemical staining was used to detect the expression levels of pro-GRP and Napsin A in the specimens,and the relationship between the expression levels of the 2 groups and the clinical prognosis of patients with lung cancer was analyzed.Results The positive expression rate of pro-GRP in lung cancer group was significantly higher than that in the control group(P<0.05)while the positive expression rate of Napsin A was significantly lower than that in the control group(P<0.05).The positive expression of pro-GRP was associated with tumor size,clinical stage,degree of differentiation and lymph node metastasis in patients with lung cancer(P<0.05),and the positive expression of Napsin A was related to the pathological type,clinical stage,differentiation degree and lymph node metastasis of patients with lung cancer(P<0.05).After 3 years of follow-up,the positive expression rate of pro-GRP in the death group was significantly higher than that in the survival group(P<0.05)while the positive expression rate of Napsin A was significantly lower than that in the survival group(P<0.05).Multivariate Cox regression analysis showed differentiation degree(γ=1.955,95%CI:1.313-2.916,P=0.002),lymph node metastasis(γ=2.584,95%CI:1.509-4.407,P=0.001),pro-GRP expression level(γ=1.581,95%CI:0.872-2.653,P<0.001)and Napsin A expression level(γ=2.063,95%CI:1.429-2.989,P<0.001)were independent risk factors affecting the clinical prognosis of patients with lung cancer.Conclusion The expression level of pro-GRP in lung cancer tissues is up-regulated while the expression level of Napsin A is down-regulated,and the expression levels of the two are cl

关 键 词：胃泌素释放肽前体 天冬氨酸肽酶A 肺癌 表达 病理特征 预后 

分 类 号：R734.2[医药卫生—肿瘤]