西达本胺维持治疗预防外周T细胞淋巴瘤患者自体外周血干细胞移植术后复发的效果和安全性  

Efficacy and Safety of Chidamide Maintenance Therapy in Preventing Recurrence after Autologous Hematopoietic Stem Cell Transplantation in Patients with Peripheral T-cell Lymphoma

作　　者：贾冉 周航 黄金 JIA Ran;ZHOU Hang;HUANG Jin(Nanyang Central Hospital,Nanyang,473000)

机构地区：[1]河南省南阳市中心医院,473000

出　　处：《实用癌症杂志》2022年第11期1895-1898,共4页The Practical Journal of Cancer

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20190012)。

摘　　要：目的研究西达本胺维持治疗预防外周T细胞淋巴瘤(PTCL)患者自体外周血干细胞移植(AHSCT)术后复发的临床效果。方法选取PTCL患者75例为研究对象,均接受AHSCT治疗,术后西达本胺维持治疗的40例患者设为观察组,其余患者设为对照组。比较2组术后治疗效果,随访半年,比较2组复发率、生存率、生存期限和不良反应发生情况。结果2组术后有效率(95.0%、88.57%)比较,无显著差异(P>0.05)。观察组无进展生存率、总生存率显著高于对照组,无进展生存期(PFS)、总生存期(OS)显著长于对照组,差异有统计学意义(P<0.05);观察组术后半年复发率(12.5%)显著低于对照组(34.3%),差异有统计学意义(P<0.05)。观察组总不良反应发生率为37.5%,均为Ⅰ~Ⅱ级不良反应。结论PTCL患者AHSCT术后予以西达本胺维持治疗,能降低复发率,延长近期生存期,提高生存率,安全事件可控,有一定临床应用价值。Objective To investigate the efficacy and safety of chidamide maintenance therapy in preventing recurrence after autologous hematopoietic stem cell transplantation(AHSCT)in patients with peripheral T-cell lymphoma(PTCL).Methods A total of 75 PTCL patients underwent AHSCT treatment were enrolled,and divided into 2 groups according to the presence or absence of postoperative chidamide treatment,the observation group(n=40)and the control group(n=35).All patients were followed up for half a year,then the clinical effect,recurrence rate,survival rate,survival time and adverse reactions were compared between the 2 groups.Results The treatment effective rate showed no obvious difference between the 2 groups(95.0%vs 88.57%,P>0.05).The progression free survival(PFS)and overall survival(OS)of observation group were obvious longer than control group(P<0.05).Half a year recurrence rate of the observation group was obvious lower than the control group(12.5%vs 34.3%,P<0.05).The overall incidence of adverse reactions in the observation group was 37.5%,all of which were gradeⅠtoⅡ.Conclusion Chidamide maintenance therapy for PTCL patients with AHSCT treatment can effectively reduce the recurrence rate,prolong the short term survival rate,which is of great clinical value.

关 键 词：外周T细胞淋巴瘤 自体外周血干细胞移植 西达本胺 复发率 安全性 

分 类 号：R733.4[医药卫生—肿瘤]