miR-155、HE4、VEGF在子宫内膜癌中的表达及与患者预后的关系  

Expression of miR-155,HE4 and VEGF in endometrial cancer and their relationship with prognosis

作　　者：苏立贞 孟洁[2] 晋婕 贾万理 杨阳[2] 刘羡伟 高楠[4] SU Lizhen;MENG Jie;JIN Jie;JIA Wanli;YANG Yang;LIU Xianwei;GAO Nan(Department of Reproductive Medicine,Xi′an High-tech Hospital,Xi′an,Shaanxi 710075,China;Department of Blood Transfusion,Xi′an High-tech Hospital Xi′an,Shaanxi 710075,China;Xi′an Kingmed Medical Laboratory Co.LTD,Xi′an,Shaanxi 710018,China;Department of Clinical Laboratory,Xi′an High-tech Hospital,Xi′an,Shaanxi 710075,China)

机构地区：[1]西安高新医院生殖医学科,陕西西安710075 [2]西安高新医院输血科,陕西西安710075 [3]西安金域医学检验所有限公司,陕西西安710018 [4]西安高新医院检验科,陕西西安710075

出　　处：《检验医学与临床》2022年第22期3062-3064,3068,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨血清微小核糖核酸-155(miR-155)、人附睾分泌蛋白4(HE4)、血管内皮生长因子(VEGF)在子宫内膜癌患者中的表达,分析其与患者预后的关系。方法收集2017年1月至2018年12月西安高新医院收治的子宫内膜癌患者102例作为癌症组,进行为期3年的随访,将出现复发、转移、死亡情况的患者纳入预后不良组(32例),其余纳入预后良好组(70例),另收集同期子宫肌瘤患者100例作为对照组。比较miR-155、HE4、VEGF在癌症组和对照组间的表达差异以及miR-155、HE4、VEGF在不同预后组间的表达差异,绘制受试者工作特征曲线分析miR-155、HE4、VEGF对子宫内膜癌预后的预测价值,采用多因素Logistic回归模型分析影响患者预后的独立危险因素。结果癌症组患者的miR-155相对表达水平及HE4、VEGF水平均明显高于对照组(P<0.05)。预后不良组患者的miR-155相对表达水平及HE4、VEGF水平均明显高于预后良好组(P<0.05)。miR-155、HE4、VEGF三者联合预测患者预后的曲线下面积为0.900,特异度和灵敏度可达90.1%、75.2%。多因素Logistic回归模型分析结果显示,miR-155相对表达水平及HE4、VEGF水平上升是患者预后不良的独立危险因素(P<0.05)。结论miR-155相对表达水平及HE4、VEGF水平在子宫内膜癌患者中明显上升,miR-155相对表达水平及HE4、VEGF水平上升是患者预后不良的独立危险因素,联合检测有助于患者预后评估。Objective To investigate the expressions of serum microRNA-155(miR-155),human epididymal secreted protein 4(HE4)and vascular endothelial growth factor(VEGF)in patients with endometrial cancer,and to analyze their relationship with prognosis.Methods A total of 102 patients with endometrial cancer admitted to Xi′an High-tech Hospital from January 2017 to December 2018 were included in the cancer group and followed up for 3 years.The patients with recurrence,metastasis and death were included in the poor prognosis group(32 cases),and the others were included in the good prognosis group(70 cases).Another 100 patients with uterine fibroids in the same period were selected as the control group.The expression differences of miR-155,HE4,and VEGF between the cancer group and the control group and the expression differences of miR-155,HE4,and VEGF between the different prognostic groups were compared.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of miR-155,HE4 and VEGF in endometrial cancer prognosis,and multivariate Logistic regression model was used to analyze the independent risk factors affecting the prognosis of patients.Results The relative expression level of miR-155 and the levels of HE4 and VEGF in cancer group were significantly higher than those in control group(P<0.05).The relative expression level of miR-155 HE4 and VEGF in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05).The area under the curve(AUC)of combined detection of miR-155,HE4,and VEGF for predicting the prognosis of patients was 0.900,with specificity and sensitivity reaching 90.1%and 75.2%,respectively.Multivariate Logistic regression model analysis showed that the increase of the relative expression level of miR-155,and the levels of HE4 and VEGF was independent risk factors of the prognosis of patients(P<0.05).Conclusion The relative expression level of miR-155 and HE4,and VEGF levels significantly increase in patients with endometrial cancer,the increase o

关 键 词：子宫内膜癌 微小核糖核酸-155 人附睾分泌蛋白4 血管内皮生长因子 预后 

分 类 号：R737.33[医药卫生—肿瘤]