Key molecules of Mucorales for COVID-19-associated mucormycosis:a narrative review  

作　　者：Priyanka Baberwal Arjun Singh Abhinav Adarsh Yatender Kumar 

机构地区：[1]Department of Biological Sciences and Engineering(BSE),Netaji Subhas University of Technology(NSUT),New Delhi,India

出　　处：《Journal of Bio-X Research》2022年第3期104-111,共8页生物组学研究杂志（英文）

摘　　要：Mucormycosis is a lethal human disease caused by fungi of the order Mucorales.Mucormycosis is caused by fungi mainly belonging to the genera Mucor,Rhizopus,and Lichtheimia,all of which belong to the order Mucorales.The number of individuals with mucormycosis-causing disorders has increased in recent years,hence,leading to the spread of mucormycosis.Throughout the coronavirus disease 2019(COVID-19)pandemic,numerous cases of mucormycosis in COVID-19-infected patients have been reported worldwide,and the illness is now recognized as COVID-19-associated mucormycosis,with most of the cases being reported from India.Immunocompromised patients such as those with bone marrow sickness and uncontrolled diabetes are at a greater risk of developing mucormycosis.Genes,pathways,and other mechanisms have been studied in Mucorales,demonstrating a direct link between virulence and prospective therapeutic and diagnostic targets.This review discusses several proteins such as high-affinity iron permease(FTR1),calcineurin,spore coat protein(CotH),and ADP-ribosylation factors involved in the pathogenesis of mucormycosis that might prove to be viable target(s)for the development of novel diagnostic and therapeutic methods.

关 键 词：ADP-ribosylation factor CALCINEURIN COVID-19-associated mucormycosis high-affinity iron permease spore coat protein 

分 类 号：R519[医药卫生—内科学]