Current role of high dose vitamin C in sepsis management:A concise review  

作　　者：Deven Juneja Prashant Nasa Ravi Jain 

机构地区：[1]Institute of Critical Care Medicine,Max Super Speciality Hospital,New Delhi 110017,India [2]Department of Critical Care Medicine,NMC Specialty Hospital,Dubai 7832,United Arab Emirates [3]Department of Critical Care Medicine,Mahatma Gandhi Medical College and Hospital,Jaipur 302022,Rajasthan,India

出　　处：《World Journal of Critical Care Medicine》2022年第6期349-363,共15页世界重症医学杂志

摘　　要：Sepsis and septic shock are common diagnoses for patients requiring intensive care unit admission and associated with high morbidity and mortality.In addition to aggressive fluid resuscitation and antibiotic therapy,several other drugs have been tried as adjuvant therapies to reduce the inflammatory response and improve outcomes.Vitamin C has been shown to have several biological actions,including anti-inflammatory and immunomodulatory effects,which may prove beneficial in sepsis management.Initial trials showed improved patient outcomes when high dose vitamin C was used in combination with thiamine and hydrocortisone.These results,along with relative safety of high-dose(supra-physiological)vitamin C,encouraged physicians across the globe to add vitamin C as an adjuvant therapy in the management of sepsis.However,subsequent largescale randomised control trials could not replicate these results,leaving the world divided regarding the role of vitamin C in sepsis management.Here,we discuss the rationale,safety profile,and the current clinical evidence for the use of highdose vitamin C in the management of sepsis and septic shock.

关 键 词：Ascorbic acid Critical care INFECTION SEPSIS Septic shock Vitamin C 

分 类 号：R459.7[医药卫生—急诊医学]