聚合酶Ⅰ和转录本释放因子:一个具有脂质代谢和免疫微环境重构功能的全新胶质瘤标记物  

Polymerase-1 and transcript release factor:a novel glioma marker with functions of lipid metabolism and immune microenvironment remodeling

作　　者：崔晓腾 康春生[1] Xiaoteng Cui;Chunsheng Kang(Lab of Neuro-oncology,Tianjin Neurological Institute,Tianjin Medical University General Hospital,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院,天津市神经病学研究所神经肿瘤研究室,天津市300052

出　　处：《中国肿瘤临床》2022年第21期1094-1097,共4页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金(编号:82073322);天津市重点研发计划科技支撑项目(编号:20YFZCSY00360)资助。

摘　　要：聚合酶Ⅰ和转录本释放因子(polymerase-1 and transcript release factor,PTRF/Cavin-1),最初因参与基因转录终止过程被报道,随后发现其可与细胞膜上小凹蛋白结合,通过参与细胞质膜小凹形成促进外泌体分泌,调节全身脂质代谢等。先天性全身性脂肪营养不良患者常见PTRF/Cavin-1基因突变/缺失。在胶质瘤中,PTRF/Cavin-1不仅可作为提示患者预后的标记物,还可通过影响肿瘤细胞内吞和外分泌、肿瘤脂质代谢重编程、重塑肿瘤细胞外基质等多种途径促进肿瘤恶性行为发生。本文归纳整理了PTRF/Cavin-1在胶质瘤中的多功能性,有助于全面理解其促进肿瘤发展的分子机制,开发针对PTRF/Cavin-1的胶质瘤靶向药物。Polymerase-1 and transcript release factor(PTRF,also known as Cavin-1)was first reported to be involved in gene transcription termination.Binding of PTRF/Cavin-1 to caveolin on the cell membrane was recently demonstrated,as was its participation in various functions,including the promotion of exosome secretion via caveolae formation and regulation of systemic lipid metabolism.PTRF/Cavin-1 gene mutation or deletion is commonly found in patients diagnosed with congenital generalized lipodystrophy.In glioma,PTRF/Cavin-1 has been identified as a marker for the prognosis of patients and promotes tumor malignant behavior by affecting endocytosis and exocrine secretion,reprogramming tumor lipid metabolism,remodeling extracellular matrix,and other functions.This review summarizes the versatility of PTRF/Cavin-1 in glioma.The information will be helpful for the comprehensive understanding of the molecular mechanism of PTRF/Cavin-1in promoting tumorigenesis and in the development of PTRF/Cavin-1 targeted drugs for precise treatment of glioma.

关 键 词：胶质瘤 PTRF/Cavin-1 细胞内吞 脂质代谢 免疫微环境 

分 类 号：R739.41[医药卫生—肿瘤]