MRI、经阴道超声联合血清CA724和HE4检测诊断卵巢癌价值  

Value of magnetic resonance imaging and transvaginal ultrasound combined with serum carbohydrate antigen and human epididymis secretory protein 4 for diagnosing ovarian cancer

作　　者：李高峰 曾兰芬[1] LI Gaofeng;ZENG Lanfen(The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangdong Province,510405)

机构地区：[1]广州中医药大学第一附属医院,510405

出　　处：《中国计划生育学杂志》2022年第11期2583-2586,共4页Chinese Journal of Family Planning

摘　　要：目的:探究磁共振成像(MRI)、经阴道超声联合糖类抗原724(CA724)、人附睾上皮分泌蛋白4(HE4)诊断卵巢癌的应用价值。方法:回顾性分析2018年9月-2021年9月在本院接受诊疗的良恶性卵巢肿瘤患者146例,均行阴道超声及MRI检查,并采用化学发光法检测血清HE4及CA724水平,以术后病理检查为标准,分为良性组(76例)和恶性组(卵巢癌)70例。分析经阴道超声、MRI联合血清CA724、HE4对卵巢癌的诊断价值。结果:恶性组血清CA724(16.65±3.07 U/ml)、HE4(176.06±23.42 pmol/L)水平均高于良性组(7.32±1.72 U/ml、74.85±13.67 pmol/L)(均P<0.05)。各指标诊断卵巢癌,HE4准确度84.9%,灵敏度85.7%,特异度84.2%;CA724准确度84.3%,灵敏度82.9%,特异度84.5%;经阴道超声准确度85.6%,灵敏度84.3%,特异度98.9%;MRI准确度90.4%,灵敏度92.9%,特异度88.2%;上述4项指标联合诊断准确度90.4%,灵敏度97.1%,特异度84.2%。结论:MRI、经阴道超声联合血清CA724、HE4检测诊断卵巢癌价值优于各单项检测。Objective:To study the value of magnetic resonance imaging(MRI)and transvaginal ultrasound combined with the levels of carbohydrate antigen(CA)724 and human epididymis secretory protein 4(HE4)for diagnosing ovarian cancer.Methods:146 patients with benign or malignant ovarian tumors from September 2018 to September 2021 were analyzed retrospectively.These patients all had undergone vaginal ultrasonography and MRI,and their serum HE4 and CA724 levels were detected by chemiluminescence method.According to the postoperative pathological examination as the standard,these patients were divided into group A(70 patients with benign tumors)and group B(76 patients with malignant tumors).The diagnostic value of transvaginal ultrasound and MRI combined with the serum CA724 and HE4 levels of the patients for their ovarian cancer was analyzed.Results:The serum levels of CA724(16.65±3.07 U/ml)and HE4(176.06±23.42 pmol/L)of the patients in group B were significantly higher than those(7.32±1.72 U/ml and 74.85±13.67 pmol/L)of the patients in group A(all P<0.05).The accuracy,the sensitivity,and the specificity of the HE4 level of the patients for diagnosing their ovarian cancer were 84.9%,85.7%,and 84.2%,respectively.The accuracy,the sensitivity,and the specificity of the CA72 level of the patients for diagnosing their ovarian cancer were4 were 84.3%,82.9%,and 84.5%,respectively.The accuracy,the sensitivity,and the specificity of the transvaginal ultrasound of the patients for diagnosing their ovarian cancer were 85.6%,84.3%,and 98.9%,respectively.The accuracy,the sensitivity,and the specificity of MRI value of the patients for diagnosing their ovarian cancer were 90.4%,92.9%,and 88.2%,respectively.The accuracy,the sensitivity,and the specificity of transvaginal ultrasound and MRI combined with the serum CA724 and HE4 levels of the patients for diagnosing their ovarian cancer were 90.4%,97.1%,and 84.2%,respectively.Conclusion:MRI and transvaginal ultrasound combined with the serum CA724 and HE4 levels of the patients for diagno

关 键 词：卵巢癌 磁共振成像 经阴道超声 糖类抗原724 人附睾上皮分泌蛋白4 诊断价值 

分 类 号：R737.31[医药卫生—肿瘤]