利培酮联合丙戊酸钠治疗精神分裂症及对改善患者认知功能的疗效分析  

Efficacy analysis of risperidone and sodium valproate in treating schizophrenia and in improving cognitive function in patients

作　　者：何新年 He Xinnian(Department of psychiatry,Yongfeng Third People's Hospital,Ji'an City,Jiangxi Province,Ji'an 34300o,China)

机构地区：[1]江西省吉安市永丰县第三人民医院,江西吉安343000

出　　处：《首都食品与医药》2022年第19期88-91,共4页Capital Food Medicine

摘　　要：目的 分析对精神分裂症患者联合应用利培酮和丙戌酸钠进行治疗后患者认知功能的改善情况.方法 选择2020年3月-2021年5月永丰县第三人民医院收治的精神分裂症患者100例作为观察对象,使用电脑随机数字表法将100例患者分为观察组和对照组各50例,对照组患者应用利培酮进行治疗,观察组患者联合应用利培酮和丙戌酸钠进行治疗,比较两组患者的治疗效果,治疗前后的BRPS、PANSS评分,认知功能,不良反应发生率及治疗满意度.结果 经过治疗后,观察组患者治疗总有效率为96.00%,明显高于对照组患者的治疗总有效率74.00%(P<0.05).经过治疗后,两组患者的BRPS、PANSS评分均有明显降低,但是观察组患者的BRPS、PANSS评分均低于对照组患者的BRPS、PANSS评分(P<0.05).经过治疗后,观察组患者较对照组完成时间更短,总应答数更多,错误应答数更少(P均<0.05).观察组患者不良反应发生率为4.00%,对照组患者的不良反应发生率为10.00%,两组患者不良反应发生率差异无统计学意义(P>0.05).观察组患者对我院的治疗满意度为96.00%,对照组患者对我院的治疗满意度为78.00%,观察组患者治疗满意度明显高于对照组(P<0.05).结论 对精神分裂症患者联合应用利培酮和丙戌酸钠进行治疗,可以有效改善治疗效果,降低患者的BRPS、PANSS评分,改善患者的认知能力,安全性高.Objective To analyze the improvement of cognitive funclion in schizophrenic patients treated with risperidone and sodium propionate.Methods 100 schizophrenic patients admited to our hospial from March 2020 to May 2021 were selected as the observation objects,1oo patients were divided into observation group and control group by computer random number table.patients in the control group were treated with risperidone,the patients in the observation group were treated with risperidone and sodium propionate,and the therapeutic effects of the two groups were compared,BRPS.PANSS score.cognitive function before and after treatment,incidence of adverse reactions and treatment satisfaction.Result Afier the treatment.the total treatment response rate of the patients in the observation group was 96.00%.which was significantly higher than the overall response rate of 74.00%in the control group patients(P<0.05).After the medical treatment,BRPS,All of the PANSS scores were significantly reduced.but in the observation group of patients with BRPS.the PANSS scores were all lower than the BRPS of the control group patients,PANSS grade.(P all<O.05).Patients in the observation group had a shorter completion time than those in the control group,more in the total number of responses,Less errors should be sent(P<0.05).After the treatment,the incidence of adverse reactions in patients in the observation group was 4.00%,the incidence of adverse reactions in the control group was 10.00%.there was no significant difference in the incidence of adverse effects in the two groups(P>0.05).The treatment satisfaction of the patients in the observation group to our hospital was 96.00%,the treatment satisfaction of the control group patients with our hospital was 78.00%.the treatment satisfaction was significantly higher than that in the control group(P<0.05).Conclusion The combination of risperidone and sodium propionate in the treatment of schizophrenia can effectively improve the therapeutic effect,reduce the BRPS and PANSS scores,improve the cog

关 键 词：利培酮 丙戌酸钠 精神分裂症 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]